Recombinant Human Interleukin 1 Receptor, Type I

Cat.No. : IL1R1-1640H
  • Specification
  • Gene Information
  • Related Products
  • Download
Cat. No. : IL1R1-1640H
Description : Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a, is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades. IL1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-1 sRI is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]
Synonyms : IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; p80; antigen CD121a; OTTHUMP00000161344; interleukin receptor 1; interleukin 1 receptor alpha, type I; Interleukin-1 receptor type I; IL-1R-1; IL-1RT1; CD121 antigen-like family member A; CD121a antigen
Gene ID : 3554
mRNA Refseq : NM_000877
Protein Refseq : NP_000868
MIM : 147810
UniProt ID : P14778
Chromosome Location : 2q12
Pathway : Apoptosis; Cytokine-cytokine receptor interactioN; Hematopoietic cell lineage; MAPK signaling pathway
Function : interleukin-1, Type I, activating receptor activity TAS; platelet-derived growth factor receptor binding; protein binding; transmembrane receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
07/14/2022

    High stability.

    06/07/2017

      Suitable for ELISA.

      04/19/2017

        Effective in signaling studies.

        Q&As (10)

        Ask a question
        How does the cellular localization of IL1R1 influence its responsiveness to ligands, and how can live-cell imaging techniques track its dynamic movement on the cell surface? 10/01/2022

        Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.

        How can advanced computational modeling and molecular dynamics simulations predict the allosteric changes in IL1R1's intracellular domain upon ligand binding, offering insights into its downstream signaling cascade? 04/19/2022

        Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.

        What are the mechanisms underlying IL1R1's dimerization and oligomerization, and how can FRET and cross-linking assays provide insights into its multimeric assembly? 12/26/2020

        FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.

        How does IL1R1's endocytosis and recycling affect its signaling duration, and how can confocal microscopy and flow cytometry unveil its intracellular trafficking patterns? 12/25/2020

        Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.

        What are the intricate molecular details of IL1R1's recruitment of MyD88 and other adapter proteins upon ligand binding, and how can co-immunoprecipitation assays reveal these interactions? 07/25/2020

        Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.

        How does the interaction between IL1R1 and accessory proteins like IL1RAP influence its ligand binding and intracellular signaling, and how can mutagenesis studies dissect these interfaces? 04/13/2020

        Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.

        How do the structural dynamics of IL1R1's extracellular domains modulate its binding to various ligands, and how can cryo-electron microscopy unveil these conformational changes? 02/22/2020

        Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.

        What are the intricate crosstalk mechanisms between IL1R1 and other receptors in cell signaling networks, and how can proteomics-based studies dissect these interconnected pathways? 01/17/2020

        Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.

        What are the complex regulatory mechanisms governing IL1R1's expression and alternative splicing, and how can CRISPR-based approaches shed light on the functional consequences of these variations? 09/09/2018

        CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.

        In what ways does IL1R1's post-translational modification landscape impact its downstream signaling, and how can phosphoproteomics offer a comprehensive view of its phosphorylation events? 09/17/2017

        Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.

        Ask a Question for All IL1R1 Products

        Required fields are marked with *

        My Review for All IL1R1 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends