Recombinant Human Interleukin 1 Receptor, Type I
- Gene Information
- Related Products
|Cat. No. :||IL1R1-1640H|
|Description :||Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a, is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades. IL1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells.|
|Source :||Mammalian cells|
|State Of Matter :||Lyophilized.|
|Purity :||>97% by SDS Page and analyzed by silver stain.|
|Endotoxin :||<1.0 EU/µg as determined by the LAL method.|
|Molecular Weight :||The predicted molecular weight of Recombinant Human IL-1 sRI is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.|
|Storage And Stability :||This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.|
|Gene Name :||IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]|
|Synonyms :||IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; p80; antigen CD121a; OTTHUMP00000161344; interleukin receptor 1; interleukin 1 receptor alpha, type I; Interleukin-1 receptor type I; IL-1R-1; IL-1RT1; CD121 antigen-like family member A; CD121a antigen|
|Gene ID :||3554|
|mRNA Refseq :||NM_000877|
|Protein Refseq :||NP_000868|
|UniProt ID :||P14778|
|Chromosome Location :||2q12|
|Pathway :||Apoptosis; Cytokine-cytokine receptor interactioN; Hematopoietic cell lineage; MAPK signaling pathway|
|Function :||interleukin-1, Type I, activating receptor activity TAS; platelet-derived growth factor receptor binding; protein binding; transmembrane receptor activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Live-cell imaging techniques track IL1R1's movement on the cell surface, revealing how cellular localization impacts its responsiveness to ligands.
Advanced computational modeling and molecular dynamics simulations predict allosteric changes in IL1R1's intracellular domain upon ligand binding, revealing insights into its downstream signaling cascade.
FRET and cross-linking assays reveal the multimeric assembly of IL1R1, shedding light on its dimerization and oligomerization dynamics.
Confocal microscopy and flow cytometry visualize IL1R1's endocytosis and recycling, offering insights into its intracellular trafficking dynamics and signaling duration.
Co-immunoprecipitation assays unravel the interactions between IL1R1 and adapter proteins, elucidating the molecular details of its intracellular signaling cascade.
Mutagenesis studies dissect the interfaces between IL1R1 and accessory proteins like IL1RAP, uncovering their roles in ligand binding and signaling modulation.
Cryo-electron microscopy captures IL1R1's structural shifts during ligand binding, unveiling conformational changes that influence its ligand recognition.
Proteomics-based studies uncover the crosstalk between IL1R1 and other receptors in signaling networks, unveiling their interconnected pathways.
CRISPR-based approaches manipulate IL1R1 expression and alternative splicing, providing functional insights into the complex regulatory mechanisms governing its variations.
Phosphoproteomics characterizes IL1R1's phosphorylation landscape, revealing how post-translational modifications shape its downstream signaling outcomes.
Customer Reviews (3)Write a review
High stability. -
Suitable for ELISA. -
Effective in signaling studies. -
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