Recombinant Human Interleukin 1 Receptor, Type I

• Cat.No.: IL1R1-1640H

Specification

• Cat. No.: IL1R1-1640H
• Description: Interleukin 1 receptor, type I (IL1R1), also known as CD121a (Cluster of Differentiation 121a, is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades. IL1R1 is expressed predominantly by T cells, fibroblasts, and endothelial cells.
• Source: Mammalian cells
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Molecular Weight: The predicted molecular weight of Recombinant Human IL-1 sRI is Mr 36 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: IL1R1 interleukin 1 receptor, type I [ Homo sapiens ]
• Synonyms: IL1R1; interleukin 1 receptor, type I; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; p80; antigen CD121a; OTTHUMP00000161344; interleukin receptor 1; interleukin 1 receptor alpha, type I; Interleukin-1 receptor type I; IL-1R-1; IL-1RT1; CD121 antigen-like family member A; CD121a antigen
• Gene ID: 3554
• mRNA Refseq: NM_000877
• Protein Refseq: NP_000868
• MIM: 147810
• UniProt ID: P14778
• Chromosome Location: 2q12
• Pathway: Apoptosis; Cytokine-cytokine receptor interactioN; Hematopoietic cell lineage; MAPK signaling pathway
• Function: interleukin-1, Type I, activating receptor activity TAS; platelet-derived growth factor receptor binding; protein binding; transmembrane receptor activity