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Recombinant Human Interleukin 31

Cat.No. : IL31-137H
Product Overview : Recombinant Human Interleukin 31 expressed inE. Coliis a 15.8 kDa protein containing 141 amino acid residues.
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Cat. No. : IL31-137H
Description : Human IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases.
Source : E. Coli.
Amino Acid Sequence : SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Supplied : Lyophilized powder.
Purity : >98% by SDS-Page analysis and HPLC analysis. Endotoxin level less than 0.1ng/ug (1EU/ug).
Reconstitution : We recommend a quick spin followed by reconstitution in sterile DI water to a concentration of 0.1-1.0 mg/ml. Allow to set at least 30 minutes at 4°C, tighten cap and rotate to reconstitute any material on sides of vial. If desired, you can centrifuge at 1000 rpm for 1 minute to concentrate volume in bottom of vial. This solution can be diluted into other buffered solutions containing carrier protein or medium containing serum and stored at 4°C(up to 1 week) or -20°Clong term).
Reactivity : In progress.
Storage : The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20°C. Reconstituted IL-31 should be stored in working aliquots at -20°C. Avoid frequent freeze thaw cycles.
Gene Name : IL31 interleukin 31 [ Homo sapiens ]
Synonyms : IL31; interleukin 31; IL-31; Interleukin-31
Gene ID : 386653
mRNA Refseq : NM_001014336
Protein Refseq : NP_001014358
MIM : 609509
UniProt ID : Q6EBC2
Chromosome Location : 12q24.31

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the advantages of IL31 compared with other therapeutic methods? 07/19/2022

The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

What is the action mechanism of IL31? 09/26/2020

IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

In what research areas is this protein used in the laboratory? 09/09/2020

It has a wide range of applications in immune inflammation, dermatology and other research fields.

How is the clinical research progress of IL31? 01/02/2020

Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

Are there some challenges in the study of IL31? 10/06/2019

IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

How to determine the optimal dose of IL31 for treatment? 01/01/2019

Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.

Customer Reviews (3)

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Reviews
04/22/2022

    IL31 product has strict quality control and complies with relevant industry standards.

    09/26/2021

      It performs well in biological activity tests.

      09/13/2020

        This protein has high yield and good economic benefits.

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