• Official Full Name

    interleukin 31

  • Background

    IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.
  • Synonyms

    IL31; interleukin 31; interleukin-31; IL 31; IL-31;
    • Type:
    • Recombinant Proteins
    • GMP Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cynomolgus
    • Dog
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    • His (Fc)
    • Avi
    • Myc
    • His(C
    • ter)
    • His|GST
    • N/A
    • N
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus IL31-312C Recombinant Cynomolgus IL31 protein, His-tagged HEK293 His
    Dog IL31-1038D Recombinant Dog IL31 Protein, His-tagged E.coli N-His
    Dog IL31-05D Recombinant Dog IL31 Protein (24-159aa) HEK293
    Dog IL31-1215D Recombinant Dog IL31 Protein (Ser24-Gln159), N-His tagged E.coli N-His
    Human IL31-4336HG GMP Recombinant Human IL31 protein E.coli N/A
    Human IL31-151H Recombinant Human IL31 Protein, His-tagged Human Cells His
    Human IL31-171H Recombinant Human IL31 Protein E.coli
    Human IL31-641H Recombinant Human IL31 protein E.coli N/A
    Human IL31-2318H Recombinant Human IL31 protein, His&Myc-tagged Insect Cell His&Myc
    Human IL31-1311H Recombinant Human IL31 protein, His&Myc-tagged HEK293 His&Myc
    Human IL31-0224H Recombinant Human IL31 protein, His-tagged HEK293 His
    Human IL31-5227HCL Recombinant Human IL31 293 Cell Lysate HEK293 N/A
    Human IL31-2311H Recombinant Human IL31 Protein, His-tagged E.coli N-His
    Human IL31-189H Recombinant Active Human IL31 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL31-4542H Recombinant Human IL31 protein, His&Myc-tagged E.coli His&Myc
    Human IL31-311H Recombinant Human IL31 protein, His-tagged HEK293 His
    Human IL31-096I Recombinant Human IL31 Protein (141 aa) E.coli
    Human IL31-284H Recombinant Human IL31 Protein, StrepII-tagged HEK293 Strep II
    Human IL31-137H Recombinant Human Interleukin 31 E.coli N/A
    Mouse Il31-156M Recombinant Mouse Il31 Protein E.coli
    Mouse IL31-172M Recombinant Mouse IL31 Protein E.coli
    Mouse Il31-1573M Recombinant Mouse Il31 protein, His-tagged E.coli His
    Mouse IL31-8167M Recombinant Mouse IL31 Protein Mammalian Cell His
    Mouse Il31-171M Recombinant Mouse Interleukin 31 E.coli N/A
    Mouse Il31-49MB Recombinant Mouse Il31 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Il31-1923M Recombinant Mouse Il31 Protein E.coli N/A
    Mouse IL31-4514M-B Recombinant Mouse IL31 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il31-01M Recombinant Mouse Il31 Protein, His-Tagged E.coli His
    Mouse Il31-48M Recombinant Mouse Il31 protein, His-tagged HEK293 His
    Mouse IL31-4514M Recombinant Mouse IL31 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il31-1574R Recombinant Rat Il31 protein, His & GST-tagged E.coli His/GST
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL31 Related Articles
    • IL31 Related Gene Family
    • IL31 Related Research Area

    IL31 involved in several pathways and played different roles in them. We selected most pathways IL31 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL31 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    IL31 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL31 itself. We selected most functions IL31 had, and list some proteins which have the same functions with IL31. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityNRG1;IFNA12;GREM1;NAMPT;GDF10B;IFNA6;CCL38A.5;FGF2;INHBAB

    IL31 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL31 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL31.

    Yu, JI; Park, YR; et al. Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis. JOURNAL OF GENETICS 93:813-817(2014).
    Maier, E; Werner, D; et al. Human Th2 but Not Th9 Cells Release IL-31 in a STAT6/NF-kappa B-Dependent Way. JOURNAL OF IMMUNOLOGY 193:645-654(2014).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What are the advantages of IL31 compared with other therapeutic methods? 07/19/2022

    The IL31 may have specificity for specific diseases, with relatively few side effects being a big advantage.

    What is the action mechanism of IL31? 09/26/2020

    IL31 activates downstream signaling pathways by binding to receptors and participates in inflammatory response and immune regulation.

    In what research areas is this protein used in the laboratory? 09/09/2020

    It has a wide range of applications in immune inflammation, dermatology and other research fields.

    How is the clinical research progress of IL31? 01/02/2020

    Clinical studies of IL31 are ongoing, but there is no clear therapeutic effect and effectiveness assessment at this time.

    Are there some challenges in the study of IL31? 10/06/2019

    IL31 research still faces many challenges, including side effect evaluation, efficacy verification and other issues, and further efforts are needed.

    How to determine the optimal dose of IL31 for treatment? 01/01/2019

    Optimal dose may be related to individual differences, disease type and other factors, and the appropriate dose should be determined under the guidance of a doctor when using IL31.

    Customer Reviews (3)

    Write a review

      It has the characteristics of high yield, high stability, high purity and strong adaptability, which provide a good basis for its clinical application. -


        The structure of IL-31 is relatively stable and it is able to maintain its stability and activity under suitable storage conditions, which is very important for preservation and stability during production and use. -


          Through proper expression and recombination techniques, the produced IL-31 has good biological activity and function, and can play the expected effect in clinical application. -

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