Recombinant Human Interleukin 33, His-tagged
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Cat.No. : | IL33-448H Optional Service: Optional requirements on this protein |
Product Overview : | Interleukin-33 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 159 amino acids C-terminal fragment (112-270) having a molecular weight of 20.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL-33 His is purified by proprietary chromatographic techniques. |
Description : | Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. |
Source : | Human |
Host : | Escherichia Coli. |
Form : | Interleukin-33 His-Tag protein is supplied in 1xPBS, 50% glycerol. |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered clear solution. |
Storage : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
PDB rendering based on 2KLL : |
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Gene Name : | IL33 interleukin 33 [ Homo sapiens ] |
Official Symbol : | IL33 |
Synonyms : | IL33; interleukin 33; DVS27; NF-HEV; NFEHEV; C9orf26; DKFZp586H0523; RP11-575C20.2; DVS27-related protein; nuclear factor from high endothelial venules; chromosome 9 open reading frame 26 (NF-HEV); IL-1F11; IL-33; IL1F11; NFHEV; OTTHUMP00000021041; Interleukin-1 family member 11; Nuclear factor from high endothelial venules |
Gene ID : | 90865 |
mRNA Refseq : | NM_033439 |
Protein Refseq : | NP_254274 |
MIM : | 608678 |
UniProt ID : | O95760 |
Chromosome Location : | 9p24.1 |
Function : | cytokine activity; protein binding |
◆ Recombinant Protein
IL33-066H | Recombinant Human IL33 Protein | +Inquiry |
Il33-157M | Recombinant Mouse Il33 Protein | +Inquiry |
Il33-5186M | Recombinant Mouse Il33 Protein | +Inquiry |
IL33-356I | Recombinant Human IL33 Protein (159 aa) | +Inquiry |
Il33-3521M | Recombinant Mouse Il33 Protein | +Inquiry |
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◆ Lysates
IL33-5226HCL | Recombinant Human IL33 293 Cell Lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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