Il33
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Official Full Name
interleukin 33
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Overview
IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011] -
Synonyms
IL33; interleukin 33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Canine
- Cynomolgus
- Dog
- Human
- Mouse
- Pig
- Rat
- CHO
- E. coli
- E.coli
- HEK293
- Human
- Human Cells
- In Vitro Cell Free System
- Insect Cells
- Mammalian Cell
- Mouse
- Wheat Germ
- Yeast
- Avi
- Fc
- Flag
- GST
- His
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Il33 involved in several pathways and played different roles in them. We selected most pathways Il33 participated on our site, such as Cytosolic DNA-sensing pathway, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytosolic DNA-sensing pathway | CCL5;POLR3C;IFNA1;IFNB1;POLR3GLB;POLR2E;Ifna11;NFKBIAA;IFNA17 |
| Influenza A | HLA-DRA;HLA-DQA2;NUP98;MAPK13;IRF3;IL1B;RNASEL;EIF2AK1;IFNA12 |
Il33 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il33 itself. We selected most functions Il33 had, and list some proteins which have the same functions with Il33. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IFNA5;BMP15;CCL4;BMP6;LTB;IL20;IFNW1;VEGFA;GDF10 |
| protein binding | SUV39H1;SIKE1;BBS5;RIN3;LPHN1;MED25;DDR2;PTGDS;CEACAM6 |
Il33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il33 here. Most of them are supplied by our site. Hope this information will be useful for your research of Il33.
HIST1H2AG; IL1RL1; CRMP1; HIST1H2BC
Gene Family
Research Area
Related articles
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- Q&As
Customer Reviews (3)
Write a reviewGood solubility and is easy to operate and purify.
Effectively mimics the function of the target protein in vitro.
IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.
Q&As (6)
Ask a questionIt can be used to detect immune cells such as macrophages and dendritic cells.
This protein applied in immunology, drug research, life science and other fields.
Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.
IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.
The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.
Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.
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