JAK3 is a member of the JAKfamily of tyrosine kinases involved in cytokine receptor-mediatedintracellular signal transduction. Low levels of JAK3 expression is detectedin immature hematopoietic cells, which dramatically increases during terminaldifferentiation of these cells suggesting a role of JAK3 in thedifferentiation of hematopoietic cells. Mutations in JAK3 are associated withautosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3show a severe block in B-cell development at the pre-B stage in bone marrowsuggesting that JAK3 is critical for the progression of B-cell development inthe bone marrow.
Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT + 50%glycerol.
Molecular Weight :
Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
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