Recombinant Human Janus Kinase 3, GST-tagged

Cat.No. : JAK3-1887H
Product Overview : Recombinant humanJAK3 catalytic domain (amino acids 781-1124), GST-tagged. No special measureswere taken to activate this kinase.
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Cat. No. : JAK3-1887H
Description : JAK3 is a member of the JAKfamily of tyrosine kinases involved in cytokine receptor-mediatedintracellular signal transduction. Low levels of JAK3 expression is detectedin immature hematopoietic cells, which dramatically increases during terminaldifferentiation of these cells suggesting a role of JAK3 in thedifferentiation of hematopoietic cells. Mutations in JAK3 are associated withautosomal SCID (severe combined immunodeficiency disease. Mice lacking JAK3show a severe block in B-cell development at the pre-B stage in bone marrowsuggesting that JAK3 is critical for the progression of B-cell development inthe bone marrow.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT + 50%glycerol.
Molecular Weight : 67.4 kDa
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : JAK3
Gene Name : JAK3 Janus kinase 3 [ Homosapiens ]
Synonyms : JAK3; Janus kinase 3; JAKL;LJAK; JAK-3; L-JAK; JAK3_HUMAN; leukocyte Janus kinase; tyrosine-proteinkinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); EC2.7.10.2
Gene ID : 3718
mRNA Refseq : NM_000215
Protein Refseq : NP_000206
MIM : 600173
UniProt ID : P52333
Chromosome Location : 19p13.1
Pathway : Chemokine signaling pathway;Jak-STAT signaling pathway; Primary immunodeficiency; HTLV-Iinfection; IL-2 Signaling Pathway; IL-4 signaling Pathway; IL-7 SignalingPathway; IL-9 Signaling Pathway; IL2 signaling events mediated by PI3K; IL4-mediatedsignaling events; Immune System; Interleukin receptor SHC signaling
Function : ATP binding; Janus kinaseactivity; non-membrane spanning protein tyrosine kinase activity; nucleotidebinding; protein binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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