JAK3

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JAK3

Official Full Name Janus kinase 3
Background Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
Synonyms JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human cells
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • C-Myc/DDK
    • DYKDDDDK
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human JAK3-151H Recombinant Human JAK3 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human JAK3-006H Recombinant Human JAK3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human JAK3-1887H Recombinant Human Janus Kinase 3, GST-tagged Insect Cell GST
    Human JAK3-252H Recombinant Human JAK3 Protein, His-tagged E.coli His
    Human JAK3-2657H Recombinant Human Janus Kinase 3, GST-His S.frugiperda His/GST
    Human JAK3-27631TH Recombinant Human JAK3 N/A
    Human JAK3-32H Recombinant Human JAK3 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human JAK3-337H Recombinant Human Janus Kinase 3, GST-tagged, Active Sf9 Insect Cell GST
    Human JAK3-466H Recombinant Human JAK3 Mammalian Cell His
    Human JAK3-467H Recombinant Human JAK3 Protein, His-tagged Insect cells His
    Human JAK3-5106HCL Recombinant Human JAK3 293 Cell Lysate HEK293 N/A
    Mouse JAK3-1672M Recombinant Mouse JAK3 Protein (818-1100 aa), His-tagged Yeast His
    Mouse Jak3-253M Recombinant Mouse Jak3 Protein, His-tagged E.coli His
    Mouse Jak3-3628M Recombinant Mouse Jak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse JAK3-8410M Recombinant Mouse JAK3 Protein Mammalian Cell His
    Chicken JAK3-6554C Recombinant Chicken JAK3 Mammalian Cell His
    Kit-1608 JAK3 Activity Assay Kit N/A

    JAK3 involved in several pathways and played different roles in them. We selected most pathways JAK3 participated on our site, such as ARMS-mediated activation, Axon guidance, CD40/CD40L signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation CSF2RA; NEFLB; CSK; PSMD9; WDR83; FGF18B; PAQR3A; SPRED3; JAK2; CRK
    Axon guidance RHOAE; FGF8B; SCN3B; MYL12B; FRS2; ARPC1B; RASGEF1A; SPNA2; SEMA3G; TRIO
    CD40/CD40L signaling MYC; JAK3; TDP2
    Chemokine signaling pathway GRK6; IKBKG; WAS; PXN; HCK; PAK1; VAV1; GRK4; STAT2; CXCL12
    Cytokine Signaling in Immune system DUSP10; FGF10B; IRF9; PAQR3B; TRIM31; KBTBD7; EIF4G2; WDR83; DUSP4; IFIT11
    DAP12 interactions RASGEF1A; AGO3; CD300LB; SPNA1; SPTB; PAQR3A; FRS2; KLB; AGO2; MOV10
    DAP12 signaling CNKSR1; FGF18B; SPTB; PEA15; MARK3; MOV10; AGO1; CSF2RB; AGO2; PEBP1
    Developmental Biology RHOB; EPHB3A; CAP2; CNKSR1; JAK1; MYOD1; SIAH2; EFNB2A; LGI4; CACNG2

    JAK3 has several biochemical functions, for example, ATP binding, hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK3 itself. We selected most functions JAK3 had, and list some proteins which have the same functions with JAK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EPHB4B; PRKAG3; PLK1; INSRA; TXK; CKMT2; DYRK1B; BUB1B; TBK1; OBSCN
    hormone receptor binding JAK3; JAK2A; TNK2; TNK1; TNK2B; JAK2B; SRC
    non-membrane spanning protein tyrosine kinase activity WEE1; MELK; WEE2; FER; CSK; BLK; BTK; LYN; SRMS; YES1
    protein binding SULT2B1; FBXO34; NAA50; EXOSC4; PTPN18; KDM4A; E2F7; SIGIRR; SGK1; NAA30
    protein phosphatase binding AP3B1; ANAPC4; PPME1; GNB2L1; KCNN4; TRAF3; PPP6R3; ROS1; HSF4; SNX3
    protein tyrosine kinase activity Aatk; FYNA; PDGFRB; DYRK1B; EPHB2B; EPHA7; EPHB4B; PTK2AB; CLK4; DYRK2

    JAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK3.

    TCP1; CCT6A; CCT8; CCT4; NAP1L1; MAGED2; LNX1; saicar; NFATC1; PKM; ERBB3

    Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
    Bauer, SM; Gehringer, M; et al. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. ANALYTICAL METHODS 6:8817-8822(2014).

    TGF

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