JAK3 involved in several pathways and played different roles in them. We selected most pathways JAK3 participated on our site, such as ARMS-mediated activation, Axon guidance, CD40/CD40L signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| ARMS-mediated activation |
PSMD9; JAK3; EGFR; FRS3; SLC14A2; SPNA1; IL17RD; RASGEF1A; AKAP9; NTF7 |
| Axon guidance |
DCC; KLB; AP2B1; EPHB6; EPHA4A; PHB; RHOAE; EZRA; KCNQ2; PAK1 |
| CD40/CD40L signaling |
MYC; JAK3; TDP2 |
| Chemokine signaling pathway |
VAV2; GNAI1; SHC4; GM1987; CCL23; SHC2; RAP1A; CCL19; ROCK1; NCF1 |
| Cytokine Signaling in Immune system |
CISH; WDR83; ARIH1; EIF4G2; GBP5; TAB1; TRIM10; HBEGF; EIF4E3; FGF18B |
| DAP12 interactions |
SIRPB1; DAB2IPB; KIR3DS1; CD300E; RASGRP4; PEBP1; SPNA1; DUSP7; DUSP10; PAQR3A |
| DAP12 signaling |
DAB2IPB; LAMTOR2; PEA15A; FRS2A; SPTA1; AGO3; RASGRP4; KBTBD7; DUSP1; SPTBN1 |
| Developmental Biology |
KIF4; MED20; TRPC3; MED31; EPHA2A; SEMA3AB; EFNA4; COL6A3; SPRED3; DPYSL2 |
JAK3 has several biochemical functions, for example, ATP binding, hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK3 itself. We selected most functions JAK3 had, and list some proteins which have the same functions with JAK3. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
MELK; CDK14; TTBK2; IGHMBP2; MYH11; NMNAT2; ACTR1B; ACSM1; ACSM2B; VCP |
| hormone receptor binding |
TNK2B; JAK3; JAK2B; TNK1; TNK2; JAK2A; SRC |
| non-membrane spanning protein tyrosine kinase activity |
PTK2BB; JAK3; PTK6B; PTK2; PTK2B; TXK; STK16; ABL2; PTK2AA; SYK |
| protein binding |
RHOT2; DAP3; HNF1A; HNRPDL; EIF3I; BAG1; C1QTNF9B-AS1; PIF1; SLC9A1; TAF7L |
| protein phosphatase binding |
PPP1R3G; STAT3; AP3B1; JAK3; ERBB2; ANAPC7; SKAP1; ANAPC5; MAP3K5; NEK2 |
| protein tyrosine kinase activity |
MAP2K5; FES; TTN; MAP2K6; MAP2K4; TYK2; FYNA; JAK2B; MAP3K9; INSRB |
JAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK3.
TCP1; CCT6A; CCT8; CCT4; NAP1L1; MAGED2; LNX1; saicar; NFATC1; PKM; ERBB3
Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
Bauer, SM; Gehringer, M; et al. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. ANALYTICAL METHODS 6:8817-8822(2014).
