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  • Official Full Name

    Janus kinase 3

  • Overview

    Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their a
  • Synonyms

    JAK3; Janus kinase 3; tyrosine-protein kinase JAK3; JAK 3; JAK3_HUMAN; JAKL; L JAK; leukocyte Janus kinase; LJAK; tyrosine protein kinase JAK3; Janus kinase 3 (a protein tyrosine kinase, leukocyte); JAK-3; L-JAK;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Insect Cell
  • Insect cells
  • Mamanlian cells
  • Mammalian Cell
  • S.frugiperda
  • Sf21
  • Sf9 Insect Cell
  • Yeast
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAK3-117H Active Recombinant Human JAK3(781-end) Protein, N-His-tagged Sf21 His 781-end
Human JAK3-27631TH Recombinant Human JAK3 N/A
Human JAK3-337H Recombinant Human Janus Kinase 3, GST-tagged, Active Sf9 Insect Cell GST
Human JAK3-466H Recombinant Human JAK3 Mammalian Cell His
Human JAK3-32H Recombinant Human JAK3 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human JAK3-2657H Recombinant Human Janus Kinase 3, GST-His S.frugiperda His/GST
Human JAK3-1887H Recombinant Human Janus Kinase 3, GST-tagged Insect Cell GST
Human JAK3-5106HCL Recombinant Human JAK3 293 Cell Lysate HEK293 N/A
Human JAK3-252H Recombinant Human JAK3 Protein, His-tagged E.coli His Trp716~Asp967
Human JAK3-006H Recombinant Human JAK3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human JAK3-467H Active Recombinant Human JAK3 Protein, His-tagged Insect cells His
Human JAK3-2377H Recombinant Human JAK3 Protein (Gly46-Thr209), N-His tagged E.coli N-His Gly46-Thr209
Human JAK3-3174H Recombinant Human JAK3 protein, His-tagged E.coli His 351-597 aa
Human JAK3-151H Recombinant Human JAK3 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human JAK3-2365HFL Recombinant Full Length Human JAK3 protein, Flag-tagged Mamanlian cells Flag
Human JAK321187H Recombinant Human JAK3 (810-1115) Protein
Human JAK3-3185H Recombinant Human JAK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human JAK3-3185H-B Recombinant Human JAK3 Protein Pre-coupled Magnetic Beads HEK293
Human JAK37392H Recombinant Human JAK3 (810-1100) Protein
Human JAK37530H Recombinant Human JAK3 (810-1104) Protein
Human JAK317212H Recombinant Human JAK3 (810-1100) (C810S) Protein
Human JAK325186H Recombinant Human JAK3 (810-1124) Protein
Mouse JAK3-8410M Recombinant Mouse JAK3 Protein Mammalian Cell His
Mouse JAK3-4669M-B Recombinant Mouse JAK3 Protein Pre-coupled Magnetic Beads HEK293
Mouse JAK3-4669M Recombinant Mouse JAK3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Jak3-3628M Recombinant Mouse Jak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Jak3-4510M Recombinant Mouse Jak3 protein, His-tagged E.coli His 818-1100aa
Mouse Jak3-253M Recombinant Mouse Jak3 Protein, His-tagged E.coli His Leu517~Ala749
Mouse JAK3-1672M Recombinant Mouse JAK3 Protein (818-1100 aa), His-tagged Yeast His 818-1100 aa
Chicken JAK3-6554C Recombinant Chicken JAK3 Mammalian Cell His
Kit-1608 JAK3 Activity Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • JAK3 Related Articles
  • JAK3 Related Gene Family
  • JAK3 Related Research Area
  • JAK3 Related Signal Pathway

JAK3 involved in several pathways and played different roles in them. We selected most pathways JAK3 participated on our site, such as ARMS-mediated activation, Axon guidance, CD40/CD40L signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
CD40/CD40L signalingJAK3;MYC;TDP2
Chemokine signaling pathwayCXCL13;GSK3B;IKBKG;CCL20;SRC;RAC2;PIK3CD;STAT2;ADRBK1
Cytokine Signaling in Immune systemKPNA3;HBEGF;IFITM2;CASPBL;CSH1;EIF4A1;EIF4E;TRIM10;TRIM14
Developmental BiologyEFNA3B;ST8SIA2;COL6A1;NR6A1;EPHB3A;MED19;SEMA3AA;MED18;MYF6

JAK3 has several biochemical functions, for example, ATP binding, hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK3 itself. We selected most functions JAK3 had, and list some proteins which have the same functions with JAK3. You can find most of the proteins on our site.

Function Related Protein
hormone receptor bindingTNK2B;JAK2A;JAK3;JAK2B;SRC;TNK1;TNK2
non-membrane spanning protein tyrosine kinase activityPRKCD;EIF2AK2;ZNF143B;CLK1;SRMS;PTK6B;MELK;ABL2;BLK
protein bindingKHDRBS1;CTNNAL1;FBXO25;APOB;FBXO5;LPAR1;LOC149950;USP4;KLHL20
protein phosphatase bindingKCNN4;MAP3K5;ANAPC7;CDC27;PPME1;PPARG;SKAP1;VCAN;TRAF2
protein tyrosine kinase activityNTRK2B;PTK2BB;MAP2K1;FGFR4;ABL1;ZAP70;TEK;Aatk;FGR

JAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK3.


Kubo, S; Yamaoka, K; et al. The JAK inhibitor, tofacitinib, reduces the T cell stimulatory capacity of human monocyte-derived dendritic cells. ANNALS OF THE RHEUMATIC DISEASES 73:2192-2198(2014).
Bauer, SM; Gehringer, M; et al. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. ANALYTICAL METHODS 6:8817-8822(2014).
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