Description : |
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc&DDK |
Molecular Mass : |
124.9 kDa |
AA Sequence : |
MAPPSEETPLIPQRSCSLLSTEAGA LHVLLPARGPGPPQRLSFSFGDHLA EDLCVQAAKASGILPVYHSLFALAT EDLSCWFPPSHIFSVEDASTQVLLY RIRFYFPNWFGLEKCHRFGLRKDLA SAILDLPVLEHLFAQHRSDLVSGRL PVGLSLKEQGECLSLAVLDLARMAR EQAQRPGELLKTVSYKACLPPSLRD LIQGLSFVTRRRIRRTVRRALRRVA ACQADRHSLMAKYIMDLERLDPAGA AETFHVGLPGALGGHDGLGLLRVAG DGGIAWTQGEQEVLQPFCDFPEIVD ISIKQAPRVGPAGEHRLVTVTRTDN QILEAEFPGLPEALSFVALVDGYFR LTTDSQHFFCKEVAPPRLLEEVAEQ CHGPITLDFAINKLKTGGSRPGSYV LRRSPQDFDSFLLTVCVQNPLGPDY KGCLIRRSPTGTFLLVGLSRPHSSL RELLATCWDGGLHVDGVAVTLTSCC IPRPKEKSNLIVVQRGHSPPTSSLV QPQSQYQLSQMTFHKIPADSLEWHE NLGHGSFTKIYRGCRHEVVDGEARK TEVLLKVMDAKHKNCMESFLEAASL MSQVSYRHLVLLHGVCMAGDSTMVQ EFVHLGAIDMYLRKRGHLVPASWKL QVVKQLAYALNYLEDKGLPHGNVSA RKVLLAREGADGSPPFIKLSDPGVS PAVLSLEMLTDRIPWVAPECLREAQ TLSLEADKWGFGATVWEVFSGVTMP ISALDPAKKLQFYEDRQQLPAPKWT ELALLIQQCMAYEPVQRPSFRAVIR DLNSLISSDYELLSDPTPGALAPRD GLWNGAQLYACQDPTIFEERHLKYI SQLGKGNFGSVELCRYDPLGDNTGA LVAVKQLQHSGPDQQRDFQREIQIL KALHSDFIVKYRGVSYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLDASR LLLYSSQICKGMEYLGSRRCVHRDL AARNILVESEAHVKIADFGLAKLLP LDKDYYVVREPGQSPIFWYAPESLS DNIFSRQSDVWSFGVVLYELFTYCD KSCSPSAEFLRMMGCERDVPALCRL LELLEEGQRLPAPPACPAEVHELMK LCWAPSPQDRPSFSALGPQLDMLWS GSRGCETHAFTAHPEGKHHSLSFST RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |