Recombinant Human LRP1 Protein, GST-tagged LRP1-4697H

Recombinant Human LRP1 Protein, GST-tagged

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Recombinant Human LRP1 Protein, GST-tagged

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Cat.No. : LRP1-4697H
Product Overview : Human LRP1 full-length ORF ( AAH45107.1, 1 a.a. - 292 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 58 kDa
AA Sequence : MLTPPLLLLLPLLSA LVAAAIDAPKTCSPK QFACRDQITCISKGW RCDGERDCPDGSDEA PEICPQSKAQRCQPN EHNCLGTELCVPMSR LCNGVQDCMDGSDEG PHCRELQGNCSRLGC QHHCVPTLDGPTCYC NSSFQLQADGKTCKD FDECSVYGTCSQLCT NTDGSFICGCVEGYL LQPDNRSCKAKNEPV DRPPVLLIANSQNIL ATYLSGAQVSTITPT STRQTTAMDFSYANE TVCWVHVGDSAAQTQ LKCARMPGLKGFVDE HTINISLSLHLCVFS KSQQEMG
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue

Gene Name : LRP1 low density lipoprotein receptor-related protein 1 [ Homo sapiens ]
Official Symbol : LRP1
Synonyms : LRP1; low density lipoprotein receptor-related protein 1; A2MR, alpha 2 macroglobulin receptor , APR; prolow-density lipoprotein receptor-related protein 1; CD91; LRP; LRP-1; type V tgf-beta receptor; apolipoprotein E receptor; alpha-2-macroglobulin receptor; TbetaR-V/LRP-1/IGFBP-3 receptor; APR; A2MR; APOER; TGFBR5; IGFBP3R; FLJ16451; MGC88725;
Gene ID : 4035
mRNA Refseq : NM_002332
Protein Refseq : NP_002323
MIM : 107770
UniProt ID : Q07954

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