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Active Recombinant Human LRRK2 (Y1699G) Protein, GST-tagged

Cat.No. : LRRK2-116H
Product Overview : Recombinant human LRRK2 (Y1699G) (968-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathic Parkinson's disease with prevalent mutations being found within the GTPase and kinase domains. LRRK2 cooperates with MET to promote efficient tumor cell growth and survival in various cancers. Down-regulation of LRRK2 in cultured tumor cells compromises MET activation and selectively reduces downstream MET signaling to mTOR and STAT3.
Source : Insect cell
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 2.6 nmol/min/mg
Molecular Mass : ~210 kDa
Purity : >70 %
Stability : 1 Year at -70 centigrade
Storage : Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05 μg/μL
Gene Name : LRRK2 leucine-rich repeat kinase 2 [ Homo sapiens ]
Official Symbol : LRRK2
Synonyms : LRRK2; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; DKFZp434H2111; FLJ45829; RIPK7; augmented in rheumatoid arthritis 17; PARK8; AURA17; DARDARIN
Gene ID : 120892
mRNA Refseq : NM_198578
Protein Refseq : NP_940980
MIM : 609007
UniProt ID : Q5S007

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the relationship between LRRK2 gene mutations and neurodevelopment? 11/30/2019

LRRK2 gene mutations may play an important role in neurodevelopment, including neural precursor cell fate determination, cell migration, and axon clumping.

What are the effects of LRRK2 gene mutations on other diseases? 10/21/2019

In addition to Parkinson's disease, LRRK2 gene mutations are also associated with an increased risk of other diseases, such as Crohn's disease, leukemia and cancer.

How to assess the prognostic impact of LRRK2 gene mutations on patients with Parkinson's disease? 08/30/2019

By analyzing the clinical and genetic data of a large number of patients, the impact of LRRK2 gene mutations on the prognosis of Parkinson's disease patients, such as age of onset, clinical symptoms, and disease progression, can be evaluated.

How do mutations in LRRK2 affect Parkinson's disease? 07/20/2019

LRRK2 gene mutations may complicate the pathogenesis of Parkinson's disease, including increased apoptosis, affecting vesicles, mitochondria, and autophagy function.

Do drugs that inhibit LRRK2 proteins have potential value in treating Parkinson's disease? 06/12/2019

Drugs that inhibit LRRK2 protein have potential value in the treatment of Parkinson's disease, but are still in clinical research and further research is needed on their efficacy and safety.

What are the ways to study the function and regulation of LRRK2 protein? 05/05/2019

The function and regulation of LRRK2 can be studied using different research methods such as cell culture models, mouse models, fruit fly models, and human induced pluripotent stem cells.

Customer Reviews (3)

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Reviews
08/07/2022

    It has an inhibitory or killing effect on specific pathogens.

    10/26/2019

      High sensitivity and specificity were found in biosensor preparation.

      02/14/2019

        Good selectivity for specific disease-related targets.

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