MAPK1-2417H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Human MAPK1 Protein (Tyr25-Ser360) with a N-His tag was expressed in E. coli.
Description :
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Source :
E. coli
Species :
Human
Tag :
N-His
Form :
Freeze-dried powder
Molecular Mass :
Predicted Molecular Mass: 42.8 kDa Accurate Molecular Mass: 43 kDa
Protein length :
Tyr25-Ser360
Endotoxin :
<1.0 EU per 1µg (determined by the LAL method).
Purity :
> 95%
Applications :
Cell culture; Activity Assays.
Stability :
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage :
Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.