Species : |
Human |
Source : |
E.coli |
Tag : |
Non |
Protein Length : |
378 amino acids |
Description : |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. |
Molecular Weight : |
69.800kDa inclusive of tags |
Biological activity : |
Specific activity: 379.25 units/ml;621.73 Units/mg |
Form : |
Liquid |
Purity : |
Proprietary Purification |
Storage buffer : |
pH: 7.50Constituents:0.79% Tris HCl, 9.24% Sucrose, 0.88% Sodium chloride, 0.003% EGTA, 0.1% Beta mercaptoethanol, 0.002% Brij, 0.012% Benzamidine, 0.003% PMSF |
Storage : |
Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : |
MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDK WRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHN MLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKV DFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALD VVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLEVLFQGPLGSAAAAAQGGG GGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGE GAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQ ILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLY KLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPS NLLSNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY LDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKV AWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL EQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETAR FQPGVLEAP |
Sequence Similarities : |
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. |