Recombinant Human MAPKAPK5 Protein (S2-Q473), Tag Free

Cat.No. : MAPKAPK5-1303H
Product Overview : Recombinant Human GG-MAPKAPK5(S2-Q473 end) Protein was expressed in Insect cell.
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Description : Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.
Source : Insect cell
Species : Human
Tag : No tag
Form : Liquid
Protein Length : S2-Q473
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name : MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 [ Homo sapiens (human) ]
Official Symbol : MAPKAPK5
Synonyms : MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; PRAK; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; MK5; MK-5; MAPKAP-K5;
Gene ID : 8550
mRNA Refseq : NM_003668
Protein Refseq : NP_003659
MIM : 606723
UniProt ID : Q8IW41

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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