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Recombinant Human MMP12 Protein, GST-tagged

Cat.No. : MMP12-5418H
Product Overview : Human MMP12 full-length ORF ( NP_002417.2, 1 a.a. - 470 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 80.4 kDa
AA Sequence : MKFLLILLLQATASGALPLNSSTSL EKNNVLFGERYLEKFYGLEINKLPV TKMKYSGNLMKEKIQEMQHFLGLKV TGQLDTSTLEMMHAPRCGVPDVHHF REMPGGPVWRKHYITYRINNYTPDM NREDVDYAIRKAFQVWSNVTPLKFS KINTGMADILVVFARGAHGDFHAFD GKGGILAHAFGPGSGIGGDAHFDED EFWTTHSGGTNLFLTAVHEIGHSLG LGHSSDPKAVMFPTYKYVDINTFRL SADDIRGIQSLYGDPKENQRLPNPD NSEPALCDPNLSFDAVTTVGNKIFF FKDRFFWLKVSERPKTSVNLISSLW PTLPSGIEAAYEIEARNQVFLFKDD KYWLISNLRPEPNYPKSIHSFGFPN FVKKIDAAVFNPRFYRTYFFVDNQY WRYDERRQMMDPGYPKLITKNFQGI GPKIDAVFYSKNKYYYFFQGSNQFE YDFLLQRITKTLKSNSWFGC
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : MMP12 matrix metallopeptidase 12 (macrophage elastase) [ Homo sapiens ]
Official Symbol : MMP12
Synonyms : MMP12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); macrophage metalloelastase; HME; macrophage elastase; matrix metalloproteinase-12; ME; MME; MMP-12; MGC138506;
Gene ID : 4321
mRNA Refseq : NM_002426
Protein Refseq : NP_002417
MIM : 601046
UniProt ID : P39900

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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