Recombinant Human MTNR1A Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MTNR1A-556H
• Product Overview: MTNR1A MS Standard C13 and N15-labeled recombinant protein (NP_005949) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 39.4 kDa
• AA Sequence: MQGNGSALPNASQPVLRGDGARPSW LASALACVLIFTIVVDILGNLLVIL SVYRNKKLRNAGNIFVVSLAVADLV VAIYPYPLVLMSIFNNGWNLGYLHC QVSGFLMGLSVIGSIFNITGIAINR YCYICHSLKYDKLYSSKNSLCYVLL IWLLTLAAVLPNLRAGTLQYDPRIY SCTFAQSVSSAYTIAVVVFHFLVPM IIVIFCYLRIWILVLQVRQRVKPDR KPKLKPQDFRNFVTMFVVFVLFAIC WAPLNFIGLAVASDPASMVPRIPEW LFVASYYMAYFNSCLNAIIYGLLNQ NFRKEYRRIIVSLCTARVFFVDSSN DVADRVKWKPSPLMTNNNVVKVDSV TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MTNR1A melatonin receptor 1A [ Homo sapiens (human) ]
• Official Symbol: MTNR1A
• Synonyms: MTNR1A; melatonin receptor 1A; melatonin receptor type 1A; MEL 1A R; mel1a receptor; MT1; MEL-1A-R
• Gene ID: 4543
• mRNA Refseq: NM_005958
• Protein Refseq: NP_005949
• MIM: 600665
• UniProt ID: P48039