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MTNR1A

  • Official Full Name

    melatonin receptor 1A

  • Overview

    This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
  • Synonyms

    MTNR1A; melatonin receptor 1A; melatonin receptor type 1A; MEL 1A R; MEL-1A-R; Mel1a melatonin receptor; Mel1a receptor; MelR; MR; MT 1; MT1; MTNR 1A; MTR1A_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bos taurus (Bovine)
  • Cattle
  • Chicken
  • Goat
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTNR1A-8164H Recombinant Human MTNR1A protein, His-tagged E.coli His Gly296~Val350
Human MTNR1A-30196TH Recombinant Human MTNR1A Wheat Germ N/A 55 amino acids
Human MTNR1A-4071HCL Recombinant Human MTNR1A 293 Cell Lysate HEK293 N/A
Human MTNR1A-556H Recombinant Human MTNR1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MTNR1A-1482HFL Recombinant Full Length Human MTNR1A Protein, C-Flag-tagged Mammalian cells Flag
Human MTNR1A-1455H-B Recombinant Human MTNR1A Protein Pre-coupled Magnetic Beads HEK293
Human MTNR1A-301234H Recombinant Human MTNR1A protein, GST-tagged E.coli GST Met1-Ile42
Human MTNR1A-5726H Recombinant Human MTNR1A Protein, GST-tagged Wheat Germ GST
Human MTNR1A-1455H Recombinant Human MTNR1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mtnr1a-8165M Recombinant Mouse Mtnr1a protein, His-tagged E.coli His Leu300~Val353
Mouse Mtnr1a-4221M Recombinant Mouse Mtnr1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bos taurus (Bovine) RFL34539BF Recombinant Full Length Bovine Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-257)
Cattle MTNR1A-8162C Recombinant Cattle MTNR1A protein, His & S-tagged E.coli His/S Gly216~Pro257 (Accession # O02769)
Goat MTNR1A-8163G Recombinant Goat MTNR1A protein, His & S-tagged E.coli His/S Gly312~Val366
Homo sapiens (Human) RFL8448HF Recombinant Full Length Human Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-350)
Mus musculus (Mouse) RFL1203MF Recombinant Full Length Mouse Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Ovis aries (Sheep) RFL25648OF Recombinant Full Length Sheep Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-366)
Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) RFL21682PF Recombinant Full Length Phodopus Sungorus Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-353)
Rattus norvegicus (Rat) RFL23708RF Recombinant Full Length Rat Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-156)
Sus scrofa (Pig) RFL3278SF Recombinant Full Length Pig Melatonin Receptor Type 1A(Mtnr1A) Protein, His-Tagged E.coli expression system His Full Length (1-154)
Chicken MTNR1A-6914C Recombinant Chicken MTNR1A Mammalian Cell His
Chicken MTNR1A-1142C Recombinant Chicken MTNR1A Protein, His-tagged E.coli N-His Gly299-Val353
Kit-1023 Tumor-derived Exosome enrichment and Quantification Assay Kit (Biological Fluids/Cell Media, Luminometric) N/A
Kit-1064 Phospho-p38 MAPK (Thr180+Tyr182) Translocation Assay Kit (Cell-Based) N/A
Kit-1430 MTNR1A CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1431 cAMP MTNR1A CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MTNR1A Related Articles
  • MTNR1A Related Gene Family

MTNR1A involved in several pathways and played different roles in them. We selected most pathways MTNR1A participated on our site, such as Neuroactive ligand-receptor interaction, Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTNR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionBDKRB2;AGTR1B;GH2;MTNR1B;DRD2A;NPBWR1;P2RX8;THRA;CSH2
Circadian entrainmentGNG12;AKR1C1;PRKG1;KCNJ6;GNG11;GUCY1A3;GNAI2;CACNA1H;GNAO1

MTNR1A has several biochemical functions, for example, hormone binding, melatonin receptor activity, organic cyclic compound binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTNR1A itself. We selected most functions MTNR1A had, and list some proteins which have the same functions with MTNR1A. You can find most of the proteins on our site.

Function Related Protein
hormone bindingNPR1;UCN2;ADIPOR1A;GPR30;TTR;CALR;MC1R;NPR2;ADIPOR2
melatonin receptor activityGPR50;MTNR1AL;MTNR1BA;MTNR1B;MTNR1C;MTNR1BB;MTNR1AA;MTNR1A
organic cyclic compound bindingSLC16A1;MTNR1A
protein bindingIFIT2;HNRPDL;GSPT2;ISYNA1;TNFRSF12A;KRT8;ERBB2;RPS15;ADRM1

MTNR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTNR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of MTNR1A.

RGS20; MTNR1B; PGRMC1; IRS4; VAPB; GNAI2; GNAI3; CNP; HSPA5; EEF1G; CALR; CANX; TMEM33; RAB10

Adamah-Biassi, EB; Zhang, Y; et al. Distribution of MT1 Melatonin Receptor Promoter-Driven RFP Expression in the Brains of BAC C3H/HeN Transgenic Mice. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 62:70-84(2014).
Arias-Santiago, S; Aneiros-Fernandez, J; et al. MTNR1A Receptor Expression in Normal and Pathological Human Salivary Glands. ANTICANCER RESEARCH 32:4765-4771(2012).
Dimitrov, R; Georgiev, G; et al. MEMBRANE MELATONIN RECEPTOR TYPE MT1 EXPRESSION IN HUMAN EJACULATED SPERMATOZOA. COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES 65:947-952(2012).
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