Recombinant Human Netrin 1, FLAG-tagged

Cat.No. : NTN1-2173H
Product Overview : Recombinant Human Netrin 1 (aa 28-604) is produced inHEK 293cell and fused at the N-terminus to a FLAG-tag. MW= 85kDa.
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Cat. No. : NTN1-2173H
Description : The Netrins (whose name means "one who guides" in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4 and G-netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others.
Source : HEK 293.
Concentration : 0.1mg/ml after reconstitution.
Purity : ≥95% (SDS-PAGE).
Formulation : Lyophilized. Contains PBS.
Specificity : Binds to human, mouse and rat receptors UNC5H and DCC.
Reconstitution : Reconstitute with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
Storage And Stability : Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Gene Name : NTN1 netrin 1 [ Homo sapiens ]
Synonyms : NTN1; netrin 1; NTN1L; Netrin-1; netrin 1, mouse, homolog of
Gene ID : 9423
mRNA Refseq : NM_004822
Protein Refseq : NP_004813
MIM : 601614
UniProt ID : O95631
Chromosome Location : 17p13-p12
Pathway : Axon guidance
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (6)

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Are there have any use of NTN1 protein in cancer immunotherapy? 09/24/2019

The targeted effect of NTN1 protein can be used to develop tumor immunotherapy drugs for the immune recognition and killing mechanism of tumors.

What are the applications of NTN1 protein in restorative and regenerative medicine? 07/21/2019

NTN1 protein can help with cell migration, proliferation, and directed growth, so it may be a potential therapeutic target for cell therapy and restorative medicine.

In which diseases does NTN1 protein play an important role? 07/13/2019

NTN1 protein not only plays an important role in the development of the nervous system, but also closely related to the occurrence and development of various diseases such as nervous system tumors, cardiovascular diseases and inflammatory diseases.

Is the NTN1 protein associated with inflammation? 06/10/2019

Yes, NTN1 protein is involved in the regulatory process of inflammatory response and may play an important role in the occurrence and development of inflammatory diseases.

What is the role of NTN1 protein in autoimmune diseases? 05/24/2019

This protein is closely related to the occurrence and progression of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, and may be involved in the regulation of autoimmune responses.

Why does NTN1 protein play a role in transplantation immunity? 02/11/2019

NTN1 protein may be involved in the regulation of graft rejection, affecting immune tolerance and treatment efficacy after transplantation. It is also a potential transplant immunotherapy target.

Customer Reviews (3)

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    It has high biological activity, high clearance rate and high safety.


      The storage conditions are broad and do not affect the activity of the protein,


        This protein is very reproducible.

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