Recombinant Human Netrin 1, FLAG-tagged

• Cat.No.: NTN1-2173H
• Product Overview: Recombinant Human Netrin 1 (aa 28-604) is produced inHEK 293cell and fused at the N-terminus to a FLAG-tag. MW= 85kDa.

Specification

• Cat. No.: NTN1-2173H
• Description: The Netrins (whose name means "one who guides" in Sanskrit) are a family of laminin-related secreted protein. In mice, human and rat, netrin-1, netrin-3/NTL2, netrin-4 and G-netrins have been cloned. Netrin-1 is predominantly expressed by floor plate cells as commissural axons extend toward the ventral midline. Netrin-1 induces axonal outgrowth, axon orientation and neuronal migration in neuronal development. It is chemoattractive for some neurons and chemorepellent for others.
• Source: HEK 293.
• Concentration: 0.1mg/ml after reconstitution.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Specificity: Binds to human, mouse and rat receptors UNC5H and DCC.
• Reconstitution: Reconstitute with 100µl sterile distilled water. Resuspended protein should be used immediately upon reconstitution to avoid loss in activity due to non-specific binding to the vial. Further dilutions should be made with medium containing 5% fetal calf serum or 0.5% BSA.
• Storage And Stability: Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
• Protein length: 28-604

Gene Information

• Gene Name: NTN1 netrin 1 [ Homo sapiens ]
• Synonyms: NTN1; netrin 1; NTN1L; Netrin-1; netrin 1, mouse, homolog of
• Gene ID: 9423
• mRNA Refseq: NM_004822
• Protein Refseq: NP_004813
• MIM: 601614
• UniProt ID: O95631
• Chromosome Location: 17p13-p12
• Pathway: Axon guidance
• Function: protein binding

Reviews

04/26/2022

It has high biological activity, high clearance rate and high safety.

02/03/2021

The storage conditions are broad and do not affect the activity of the protein,

01/27/2019

This protein is very reproducible.

Q&As

Are there have any use of NTN1 protein in cancer immunotherapy?

The targeted effect of NTN1 protein can be used to develop tumor immunotherapy drugs for the immune recognition and killing mechanism of tumors.

What are the applications of NTN1 protein in restorative and regenerative medicine?

NTN1 protein can help with cell migration, proliferation, and directed growth, so it may be a potential therapeutic target for cell therapy and restorative medicine.

In which diseases does NTN1 protein play an important role?

NTN1 protein not only plays an important role in the development of the nervous system, but also closely related to the occurrence and development of various diseases such as nervous system tumors, cardiovascular diseases and inflammatory diseases.

Is the NTN1 protein associated with inflammation?

Yes, NTN1 protein is involved in the regulatory process of inflammatory response and may play an important role in the occurrence and development of inflammatory diseases.

What is the role of NTN1 protein in autoimmune diseases?

This protein is closely related to the occurrence and progression of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, and may be involved in the regulation of autoimmune responses.

Why does NTN1 protein play a role in transplantation immunity?

NTN1 protein may be involved in the regulation of graft rejection, affecting immune tolerance and treatment efficacy after transplantation. It is also a potential transplant immunotherapy target.