| Species : |
Human |
| Source : |
E.coli |
| Tag : |
Non |
| Description : |
NRAS proteins aremembers of the superfamily of small GTPbinding proteins that function asmolecular switches controlling a variety of signalling and transportpathways. NRAS is one of the classic humanRas proteins (H-, N-, K-Ras4A, and K-Ras4B). NRASdeltaC comprises the first 167 residues of Ras that are sufficient forbinding guanine nucleotides and hydrolysis of GTP, but lacks the C-terminalCaaX motif necessary for membrane localization of Ras. Protein preparation is100% GDP-loaded, measured by HPLC. |
| Form : |
Liquid solution in64 mM Tris-HCl Buffer, pH 7.2, + 10 Mm MgCl2 + 5 mM DTE. |
| Purity : |
> 95%as determined by SDS-PAGE analysis |
| Applications : |
In vitro transcriptionassays; DNA-protein interaction assays; Protein-protein interaction assays. |
| storage : |
Store at-80°C. Stablefor 1 year. For long term storage, aliquot and freeze at -80°C. Avoidrepeated freeze-thaw cycles. |
| OfficialSymbol : |
NRAS |
| Pathways : |
Acute myeloid leukemia; Axonguidance; B cell receptor signaling pathway; Bladder cancer; Chemokinesignaling pathway; Chronic myeloid leukemia; Endometrial cancer; ErbBsignaling pathway; Fc epsilon RI signaling pathway; Gap junction; Glioma;GnRH signaling pathway; Insulin signaling pathway; Long-term depression;Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma;Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway;Non-small cell lung cancer; Pathways in cancer; Prostate cancer; Regulationof actin cytoskeleton; Renal cell carcinoma; T cell receptor signalingpathway; Thyroid cancer; Tight junction; VEGF signaling pathway |
