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NRAS

  • Official Full Name

    neuroblastoma RAS viral (v-ras) oncogene homolog

  • Overview

    This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia
  • Synonyms

    NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog; GTPase NRas; N ras; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog; NS6; ALPS4; N-ras; NRAS1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Bacterial expression system
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • biotinylated
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NRAS-165H Recombinant Human NRAS protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NRAS-1279H Recombinant Human Neuroblastoma RAS Viral (v-ras) Oncogene Homolog E.coli N/A
Human NRAS-447H Recombinant Human NRAS Protein, His-tagged E.coli His Met1-Cys186
Human NRAS-30411TH Recombinant Human NRAS Protein E.coli N/A
Human NRAS-3702HCL Recombinant Human NRAS 293 Cell Lysate HEK293 N/A
Human NRAS-6750HF Recombinant Full Length Human NRAS Protein, GST tagged E.coli GST
Human NRAS-01H Active Recombinant Human NRAS Protein, His-tagged Bacterial expression system His
Human NRAS-1544H Recombinant Human NRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NRAS-6106H Recombinant Human NRAS Protein, GST-tagged Wheat Germ GST
Human NRAS-172HFL Recombinant Full Length Human NRAS Protein, C-Flag-tagged Mammalian cells Flag
Human NRAS-0933H Recombinant Human NRAS Protein (T2-K169, Q61L), GST tagged E.coli GST T2-K169, Q61L
Human NRAS-0936H Recombinant Human NRAS Protein (T2-K169, Q61H), Tag Free E.coli No tag T2-K169, Q61H
Human NRAS-3519H Recombinant Human NRAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NRAS-0932H Recombinant Human NRAS Protein (T2-K169, Q61K), Tag Free E.coli No tag T2-K169, Q61K
Human NRAS-0935H Recombinant Human NRAS Protein (T2-K169, Q61H), GST tagged E.coli GST T2-K169, Q61H
Human NRAS-0937H Recombinant Human NRAS Protein (T2-K169, Q61R), GST tagged E.coli GST T2-K169, Q61R
Human NRAS-0929H Recombinant Human NRAS Protein (T2-K169), Tag Free E.coli No tag T2-K169
Human NRAS-0934H Recombinant Human NRAS Protein (T2-K169, Q61L), Tag Free E.coli No tag T2-K169, Q61L
Human NRAS-0940H Recombinant Human NRAS Protein (M1-K169), Biotinylated tagged E.coli biotinylated M1-K169
Human NRAS-0938H Recombinant Human NRAS Protein (T2-K169, Q61R), Tag Free E.coli No tag T2-K169, Q61R
Human NRAS-0930H Recombinant Human NRAS Protein (T2-K169), GST tagged E.coli GST T2-K169
Human NRAS-0941H Recombinant Human NRAS Protein (M1-K169, G13D), Biotinylated tagged E.coli biotinylated M1-K169, G13D
Human NRAS-0942H Recombinant Human NRAS Protein (M1-K169, Q61K), Biotinylated tagged E.coli biotinylated M1-K169, Q61K
Human NRAS-0939H Recombinant Human NRAS Protein (M1-K169, G12D), Biotinylated tagged E.coli biotinylated M1-K169, G12D
Human NRAS-0931H Recombinant Human NRAS Protein (T2-K169, Q61K), GST tagged E.coli GST T2-K169, Q61K
Human NRAS-0943H Recombinant Human NRAS Protein (M1-K169, Q61R), Biotinylated tagged E.coli biotinylated M1-K169, Q61R
Human NRAS-1544H-B Recombinant Human NRAS Protein Pre-coupled Magnetic Beads HEK293
Human NRAS-4434H Recombinant Human NRAS protein, 10xHis-GST&Myc-tagged E.coli His-GST&Myc 1-186aa
Mouse Nras-4494M Recombinant Mouse Nras Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NRAS-4076R Recombinant Rat NRAS Protein Mammalian Cell His
Rat NRAS-3735R Recombinant Rat NRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NRAS-3735R-B Recombinant Rat NRAS Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey NRAS-756C Recombinant Cynomolgus NRAS Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey NRAS-500C Recombinant Cynomolgus Monkey NRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey NRAS-500C-B Recombinant Cynomolgus Monkey NRAS Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NRAS-8760Z Recombinant Zebrafish NRAS Mammalian Cell His
Chicken NRAS-1922C Recombinant Chicken NRAS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • NRAS Related Signal Pathway

NRAS involved in several pathways and played different roles in them. We selected most pathways NRAS participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPTPRR;DUSP16;ACVR1C;IKBKG;CASP3A;NTRK1;GNA12;FGF21;PRKCBB
ErbB signaling pathwayPLCG2;STAT5A;ABL1;AKT2;CAMK2A;GSK3B;MAP2K4A;HRASA;MAP2K1
Ras signaling pathwayRELA;RGL2;RASAL1;AKT2;GNG7;STK4;RRAS2;RAB5B;PLD2
Rap signaling pathwayITGA2B;PIK3CB;FGF6;PRKD1;MAP2K3;SIPA1L1;HRAS;TLN1;FGF17
Chemokine signaling pathwayPRKACB;PARD3;GNB1;PLCB1;GNG11;CXCL10;CCL3L3;CCL4;CX3CL1
FoxO signaling pathwayFBXO32;KLF2B;IRS4;NLK1;PIK3R2;PIK3CG;EGFRA;GABARAPA;AKT2L
Sphingolipid signaling pathwayPPP2R2A;S1PR5;PPP2R5D;TNFRSF1A;ABCC1;MAPK8;SGMS1;TNF;MS4A2
Phospholipase D signaling pathwayPLD1;PLA2G4C;PPAP2C;SHC3;F2R;FCER1G;DGKZ;RRAS2;HRAS
PIK-Akt signaling pathwayITGB5;FGFR4;Reln;EPO;GH2;PCK1;GHR;HGF;VTN
Axon guidanceMYL9;EFNA1;COL4A5;RGMB;MAPK3;FRS2;CNKSR1;EVL;ABLIM1
VEGF signaling pathwayPIK3R3;PPP3R1;HSPB1;MAPK1;PIK3CD;PRKCB;RAC1A;AKT1;RAC1
Tight junctionCRB3A;CDC42;F11R;CLDN2;CLDNG;MYL5;CTTN;SHROOM4;CLDN15LB
Gap junctionGJD2;PLCB3;RAF1A;GNAI1;MAP3K2;GNAIA;GJA1;ITPR3;GRB2A
Signaling pathways regulating pluripotency of stem cellsBMPR1B;WNT4;FZD6;WNT1;WNT5B;WNT16;ACVR1C;BMI1;LIF
Natural killer cell mediated cytotoxicityPPP3CA;IFNAR2;KIR2DS3;IFNGR1;FCGR3B;PPP3R2;KIR2DL4;KIR2DS2;IFNB1
T cell receptor signaling pathwayRAF1;GRAPA;PLCG1;PIK3R1;NFATC1;PAK6;LCP2;CARD11;CBL
B cell receptor signaling pathwayVAV1;NFKBIB;BANK1;CD79B;MAPK4;PIK3CB;PPP3CA;TTC6;DOK1
Fc epsilon RI signaling pathwayLAT;MAPK3;PLA2G4C;VAV3;PLA2G4A;IL4;PIK3CG;PLA2G4F;RAC3
Long-term potentiationPPP3R2;GRM1;CAMK2G;GRIN2D;PPP1CA;PRKCG;RAP1A;PPP1CC;EP300
Neurotrophin signaling pathwayMAP2K1;PIK3R1;TP73;BCL2;CALML5;MAPK13;RPS6KA5;RHOA;PIK3R3
Cholinergic synapseATF4;CHRNB4;AKT2;PRKACG;CAMK4;GNG13;SLC5A7;KCNJ12;CHRNB2
Serotonergic synapsePTGS2;PTGS1;PLCB1;KRAS;PLA2G4F;HTR2A;HTR5A;PLCB4;HTR3A
Long-term depressionGUCY1A3;MAP2K1;RAF1;GRIA1;NRAS;LYN;PLCB1;GNA12;PPP2R1B
Regulation of actin cytoskeletonF2;FGF12A;PIK3R3;GNA12;FGFR4;VCL;PTK2AB;ARHGEF7A;FGF20
Insulin signaling pathwayMAPK10;MAP2K2B;PHKG1B;PTPRFB;RPTOR;FASN;PIK3CA;INPPL1;BAD
GnRH signaling pathwayPLCB3;MAPK1;PRKCB;FSHB;GNA11;GNRHR2;KRAS;MAPK12B;PLD1A
Estrogen signaling pathwayGNAS;FKBP5;CREB3L2;GNAO1;PIK3CA;CALML5;HSPA1B;PRKACB;HSPA6
MelanogenesisCALM;ADCY2B;CALM1B;KIT;WNT2BA;MITF;TCF7L2;WNT9A;MC1R
Prolactin signaling pathwayCCND2;ELF5;SOCS4;SHC2;PRL;MAPK1;SOCS1;CSN2;SHC4
Thyroid hormone signaling pathwayMED12L;ITGAV;TSC2;MAP2K2;BAD;EP300;MED13L;RXRG;TBC1D4
Oxytocin signaling pathwayPIK3R5;CAMK2B;RYR1;PRKAG1;CALM3;NFATC4;RYR3;CALM1;RYR2
AlcoholismNPY;GNB4;HIST1H4F;FOSB;HIST1H4B;GNG3;SOS1;NTRK2;BDNF
Hepatitis COAS3;MAPK8;EIF2AK1;MAPK3;BRAF;OCLN;IKBKE;PPP2R1A;IKBKG
Hepatitis BSTAT5B;CREB3L2;PIK3R1;PIK3R3;STAT6;TGFBR1;YWHAB;RB1;OSTN
HTLV-I infectionHLA-DRB4;NFATC3;PPP3R2;ELK4;ATM;RANBP3;RANBP1;TBPL1;ITGB2L
Pathways in cancerFAS;CUL2;NFKBIA;MAPK9;PTGER2;NTRK1;BIRC8;EGLN1;TGFBR2
Viral carcinogenesisHDAC3;YWHAE;SRC;HIST1H2BQ;GTF2H2C;GTF2E2;HLA-E;HDAC11;CCNE2
Proteoglycans in cancerFZD7;Casp3;CTTN;WNT5A;FGFR1;HIF1A;MMP2;ARHGEF12;PIK3R2
MicroRNAs in cancerPdgfa&Pdgfb;HMGA2;NRAS;DNMT1;MDM4;EZR;MET;SOCS1;MAPK1
Renal cell carcinomaPIK3R3;PTPN11;MAP2K2;EPAS1;EP300;VEGFA;FH;MAP2K1;HIF1A
Endometrial cancerNRAS;GRB2;MAPK3;CTNNA3;BAD;BRAF;RAF1;PIK3CB;AKT1
GliomaIGF1R;TP53;CAMK2B;AKT1;PIK3CD;BRAF;PLCG2;PDGFRA;PDGFA
Prostate cancerEP300;INS1;HRAS;TGFA;TCF7;PDPK1;INS;TCF7L2;PDGFC
Thyroid cancerTPR;TCF7L2;MAPK1;LEF1;MAPK3;MAP2K2;HRAS;RET;RXRB
MelanomaFGF8;FGF1;PDGFA;HRAS;FGF4;NRAS;PIK3R3;BRAF;AKT1
Bladder cancerMDM2;RPS6KA5;E2F3;VEGFA;MAPK1;ERBB2;CDH1;MMP2;RASSF1
Chronic myeloid leukemiaPIK3CB;CRKL;PIK3CA;TGFB3;CRK;TGFB2;AKT1;NFKBIA;CBLB
Acute myeloid leukemiaSTAT5A;AKT3;RUNX1T1;JUP;PML;ZBTB16;RELA;SPI1;GRB2
Non-small cell lung cancerRASSF5;SOS1;EML4;CCND1;PIK3R5;HRAS;MAP2K1;ERBB2;FHIT
Central carbon metabolism in cancerERBB2;MET;FLT3;NTRK1;NTRK3;HK3;PIK3R1;PKM2;PGAM1
Choline metabolism in cancerRALGDS;WASF2;TSC1;PLD1;PIK3CG;PIK3R1;PIP5K1C;NRAS;PIK3CD

NRAS has several biochemical functions, for example, GTP binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRAS itself. We selected most functions NRAS had, and list some proteins which have the same functions with NRAS. You can find most of the proteins on our site.

Function Related Protein
GTP bindingTUBG1;RAB40C;RAB43;RAB32A;SAR1AB;SRPRB;RAB33B;RAP1B;EFTUD1
protein complex bindingARRB2;NSF;INS2;Ctsl;PAFAH1B1;RNF40;TWF1;CTSL2;ERCC8

NRAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRAS here. Most of them are supplied by our site. Hope this information will be useful for your research of NRAS.

gtp; q46342_closo; Pik3ca; FBP2; RGL2; FRAT2; ALDOB; RASA1; XPA; DNAJB1; SRI; AKT1; STX17; RPS20; PPP2CB; EEF1A1; FANCC; CYLC2; SMAD1; MAPKAPK3

Research Area

Related articles

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Ciombor, KK; Wu, C; et al. Recent Therapeutic Advances in the Treatment of Colorectal Cancer. ANNUAL REVIEW OF MEDICINE, VOL 66 66:83-95(2015).
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