Recombinant Human NGFR, Fc-tagged
Cat.No. : | NGFR-30619TH |
Product Overview : | Recombinant fragment corresponding to amino acids 1-250 of Human p75 NGF Receptor fused to the Fc region of Human IgG1 expressed in modified Human 293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. |
Conjugation : | Fc |
Biological activity : | The ED50 of this chimera is typically 0.7 - 1.0 ug/ml as measured by its ability to neutralize beta NGF mediated proliferation of the human growth factor dependent TF-1 cell line. |
Form : | Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not rec |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS |
Storage : | Store at +4°C. |
Sequences of amino acids : | Theoretical sequence:KEACPTGLYTHSGECCKACNLGEGV AQPC GANQTVCEPCLDSVTFSDVVSATEP CKPCTECVGLQSM SAPCVEADDAVCRCAYGYYQDETTG RCEACRVCEAGSGLV FSCQDKQNTVCEECPDGTYSDEANH VDPCLPCTVCEDT ERQLRECTRWADAECEEIPGRWITR STPPEGSDSTAPS TQEPEAPPEQDLIASTVAGVVTTVM GSSQPVVTRGTTDNG SSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLF PPKPKDTLMISRTPEVTCVVVDVSH EDPEVKFNWYVDGVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKE YKC KVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELT KNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFS CSVMHEALHNHYT QKSLSLSPGK |
Sequence Similarities : | Contains 1 death domain.Contains 4 TNFR-Cys repeats. |
Gene Name : | NGFR nerve growth factor receptor [ Homo sapiens ] |
Official Symbol : | NGFR |
Synonyms : | NGFR; nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; CD271; low affinity nerve growth factor receptor; p75NTR; TNFR superfamily; member 16; TNFRSF16; |
Gene ID : | 4804 |
mRNA Refseq : | NM_002507 |
Protein Refseq : | NP_002498 |
MIM : | 162010 |
Uniprot ID : | P08138 |
Chromosome Location : | 17q21-q22 |
Pathway : | Axonal growth inhibition (RHOA activation), organism-specific biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; |
Function : | death receptor activity; nerve growth factor binding; protein binding; receptor activity; signal transducer activity; |
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◆ Lysates | ||
NGFR-1679MCL | Recombinant Mouse NGFR cell lysate | +Inquiry |
NGFR-1670HCL | Recombinant Human NGFR cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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