Recombinant Human NPHS2 Protein, GST-tagged

• Cat.No.: NPHS2-6032H
• Product Overview: Human NPHS2 full-length ORF ( AAH29141.1, 1 a.a. - 315 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN). SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 60.8 kDa
• AA Sequence: MERRARSSSRESRGRGGRTPHKENK RAKAERSGGGRGRQEAGPEPSGSGR AGTPGEPRAPAATVVDVDEVRGSGE EGTEVVALLESERPEEGTKSSGLGA CEWLLVLISLLFIIMTFPFSIWFCV KVVQEYERVIIFRLGHLLPGRAKGP GLFFFLPCLDTYHKVDLRLQTLEIP FHEVALDSVTCIWGIKVERIEIKDV RLPAGLQHSLAVEAEAQRQAKVRMI AAEAEKAASESLRMAAEILSGTPAA VQLRYLHTLQSLSTEKPSTVVLPLP FDLLNCLSSPSNRTQGSLPFPSPSK PVEPLNPKKKDSPML
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NPHS2 podocin [ Homo sapiens ]
• Official Symbol: NPHS2
• Synonyms: NPHS2; podocin; PDCN; SRN1
• Gene ID: 50521