Recombinant Human NR3C1 Protein, GST-tagged

• Cat.No.: NR3C1-6090H
• Product Overview: Human NR3C1 full-length ORF ( NP_000167.1, 1 a.a. - 777 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 112.1 kDa
• AA Sequence: MDSKESLTPGREENPSSVLAQERGD VMDFYKTLRGGATVKVSASSPSLAV ASQSDSKQRRLLVDFPKGSVSNAQQ PDLSKAVSLSMGLYMGETETKVMGN DLGFPQQGQISLSSGETDLKLLEES IANLNRSTSVPENPKSSASTAVSAA PTEKEFPKTHSDVSSEQQHLKGQTG TNGGNVKLYTTDQSTFDILQDLEFS SGSPGKETNESPWRSDLLIDENCLL SPLAGEDDSFLLEGNSNEDCKPLIL PDTKPKIKDNGDLVLSSPSNVTLPQ VKTEKEDFIELCTPGVIKQEKLGTV YCQASFPGANIIGNKMSAISVHGVS TSGGQMYHYDMNTASLSQQQDQKPI FNVIPPIPVGSENWNRCQGSGDDNL TSLGTLNFPGRTVFSNGYSSPSMRP DVSSPPSSSSTATTGPPPKLCLVCS DEASGCHYGVLTCGSCKVFFKRAVE GQHNYLCAGRNDCIIDKIRRKNCPA CRYRKCLQAGMNLEARKTKKKIKGI QQATTGVSQETSENPGNKTIVPATL PQLTPTLVSLLEVIEPEVLYAGYDS SVPDSTWRIMTTLNMLGGRQVIAAV KWAKAIPGFRNLHLDDQMTLLQYSW MFLMAFALGWRSYRQSSANLLCFAP DLIINEQRMTLPCMYDQCKHMLYVS SELHRLQVSYEEYLCMKTLLLLSSV PKDGLKSQELFDEIRMTYIKELGKA IVKREGNSSQNWQRFYQLTKLLDSM HEVVENLLNYCFQTFLDKTMSIEFP EMLAEIITNQIPKYSNGNIKKLLFH QK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [ Homo sapiens ]
• Official Symbol: NR3C1
• Synonyms: NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); GRL, nuclear receptor subfamily 3, group C, member 1; glucocorticoid receptor; GR; glucocorticoid nuclear receptor variant 1; GCR; GRL; GCCR
• Gene ID: 2908
• mRNA Refseq: NM_000176
• Protein Refseq: NP_000167
• UniProt ID: P04150