Recombinant Human NTRK2 Protein (Cys32-His430), His tagged
Cat.No. : | NTRK2-2617H |
Product Overview : | Recombinant human TrKB (Cys32-His430) protein fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptors with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. Other neurotrophins include nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 42.71 kDa |
Protein Length : | Cys32-His430 |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | NTRK2 neurotrophic tyrosine kinase, receptor, type 2 [ Homo sapiens (human) ] |
Official Symbol : | NTRK2 |
Synonyms : | NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; TRKB; trkB tyrosine kinase; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B; trk-B; GP145-TrkB; |
Gene ID : | 4915 |
mRNA Refseq : | NM_001007097 |
Protein Refseq : | NP_001007098 |
MIM : | 600456 |
UniProt ID : | Q16620 |
Products Types
◆ Recombinant Protein | ||
Ntrk2-4523M | Recombinant Mouse Ntrk2 Protein, Myc/DDK-tagged | +Inquiry |
NTRK2-2937R | Recombinant Rhesus Macaque NTRK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
NTRK2-470H | Recombinant Human NTRK2 Protein, Fc-tagged | +Inquiry |
NTRK2-379H | Recombinant Human NTRK2 Protein, His-tagged | +Inquiry |
NTRK2-4467H | Recombinant Human NTRK2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
NTRK2-1024CCL | Recombinant Canine NTRK2 cell lysate | +Inquiry |
NTRK2-1843MCL | Recombinant Mouse NTRK2 cell lysate | +Inquiry |
NTRK2-2683HCL | Recombinant Human NTRK2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1629 | TrkB Functional Assay Kit | +Inquiry |
Kit-1547 | U2OS TrkB Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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