Recombinant Human PCSK9 Protein, His-tagged PCSK9-03H

Recombinant Human PCSK9 Protein, His-tagged


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Recombinant Human PCSK9 Protein, His-tagged

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Cat.No. : PCSK9-03H
Product Overview : Recombinant Human PCSK9 Protein (31-692) with a N-terminal His-tag was isolated from a HEK293 overexpression system.
Description : This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : His
Bio-activity : Qualitative biological assay-reduces uptake of LDL-DyLight by >30% in Huh7 cells at concentrations above 5 μg/mL.
Molecular Mass : 71 kDa
Purity : ≥ 90% estimated by SDS-PAGE
Stability : ≥ 9 months
Storage : Store at -20 centigrade
Concentration : 200 μg/mL
Storage Buffer : Lyophilized from PBS, pH 7.4, with 30% sucrose
Reconstitution : Reconstitution in serum-free media or sterile buffer.

Lane 1: MW Markers
Lane 2: PCSK(1 μg)
Lane 3: PCSK(2 μg)

Gene Name : PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens (human) ]
Official Symbol : PCSK9
Synonyms : PCSK9; proprotein convertase subtilisin/kexin type 9; FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; convertase subtilisin/kexin type 9 preproprotein; neural apoptosis regulated convertase 1; subtilisin/kexin-like protease PC9; EC 3.4.21.-
Gene ID : 255738
mRNA Refseq : NM_174936
Protein Refseq : NP_777596
MIM : 607786
UniProt ID : Q8NBP7
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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