Recombinant Human PFN1 Protein, His-tagged
Cat.No. : | PFN1-429H |
Product Overview : | Recombinant Human PFN1(Met1~Gln139) fused with His tag at N-terminal was expressed in E. coli. |
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Description : | This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 16.4kDa |
Protein length : | Met1~Gln139 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | PFN1 profilin 1 [ Homo sapiens ] |
Official Symbol : | PFN1 |
Synonyms : | PFN1; profilin 1; profilin-1; profilin I; |
Gene ID : | 5216 |
mRNA Refseq : | NM_005022 |
Protein Refseq : | NP_005013 |
MIM : | 176610 |
UniProt ID : | P07737 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe manufacturer ensures that the protein is produced with utmost purity and integrity, minimizing the risk of experimental artifacts or compromised results.
Their excellent technical support, commitment to scientific collaboration, and efficient supply chain management greatly contribute to the success and productivity of my research.
One of the key advantages of using PFN1 protein in trials is its high quality.
Q&As (5)
Ask a questionYes, PFN1 is involved in processes such as endocytosis, cytokinesis, and cell signaling, highlighting its importance in various cellular functions.
Research on targeting PFN1 in cancer therapy is ongoing, and there are clinical trials exploring potential drugs that could inhibit PFN1 activity to impede cancer cell metastasis.
PFN1 has been found to promote cancer cell migration and invasion, suggesting its role in cancer metastasis, making it a potential target for cancer therapy.
Yes, researchers are exploring the potential of developing drugs that target PFN1 to modulate its activity, especially in the context of cancer metastasis and neurodegenerative disorders.
PFN1 regulates cell motility and migration by controlling the dynamics of actin filaments, essential components of the cell's cytoskeleton involved in cell movement.
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