Recombinant Human PLAU Protein (Ser21-Leu431), N-6×His tagged

• Cat.No.: PLAU-23H
• Product Overview: Recombinant Human PLAU Protein (Ser21-Leu431) with N-6×His tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: E. coli
• Species: Human
• Tag: N-6×His
• Form: Liquid
• Molecular Mass: 46 kDa
• Protein Length: Ser21-Leu431
• Purity: > 95%
• Applications: ELISA, Western blotting, Dot Blotting, Immunogen, Protein Array, ELISA, Western blotting, Dot Blotting, Immunogen, Protein Array
• Storage: Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution in 100 mM NaH2PO4, 10 mM Tris-HCl, 8 M urea , 10 mM imidazole and 0.5 mM EDTA (pH 8.0).
• Shipping: Ice packs

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens (human) ]
• Official Symbol: PLAU
• Synonyms: PLAU; plasminogen activator, urokinase; ATF; QPD; UPA; URK; u-PA; BDPLT5; urokinase-type plasminogen activator; U-plasminogen activator; plasminogen activator, urinary; EC 3.4.21.73
• Gene ID: 5328
• mRNA Refseq: NM_002658
• Protein Refseq: NP_002649
• MIM: 191840
• UniProt ID: P00749