| Description : |
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97 kDa |
| AA Sequence : |
MALVLGSLLLLGLCGNSFSGGQPSS TDAPKAWNYELPATNYETQDSHKAG PIGILFELVHIFLYVVQPRDFPEDT LRKFLQKAYESKIDYDKPETVILGL KIVYYEAGIILCCVLGLLFIILMPL VGYFFCMCRCCNKCGGEMHQRQKEN GPFLRKCFAISLLVICIIISIGIFY GFVANHQVRTRIKRSRKLADSNFKD LRTLLNETPEQIKYILAQYNTTKDK AFTDLNSINSVLGGGILDRLRPNII PVLDEIKSMATAIKETKEALENMNS TLKSLHQQSTQLSSSLTSVKTSLRS SLNDPLCLVHPSSETCNSIRLSLSQ LNSNPELRQLPPVDAELDNVNNVLR TDLDGLVQQGYQSLNDIPDRVQRQT TTVVAGIKRVLNSIGSDIDNVTQRL PIQDILSAFSVYVNNTESYIHRNLP TLEEYDSYWWLGGLVICSLLTLIVI FYYLGLLCGVCGYDRHATPTTRGCV SNTGGVFLMVGVGLSFLFCWILMII VVLTFVFGANVEKLICEPYTSKELF RVLDTPYLLNEDWEYYLSGKLFNKS KMKLTFEQVYSDCKKNRGTYGTLHL QNSFNISEHLNINEHTGSISSELES LKVNLNIFLLGAAGRKNLQDFAACG IDRMNYDSYLAQTGKSPAGVNLLSF AYDLEAKANSLPPGNLRNSLKRDAQ TIKTIHQQRVLPIEQSLSTLYQSVK ILQRTGNGLLERVTRILASLDFAQN FITNNTSSVIIEETKKYGRTIIGYF EHYLQWIEFSISEKVASCKPVATAL DTAVDVFLCSYIIDPLNLFWFGIGK ATVFLLPALIFAVKLAKYYRRMDSE DVYDDVETIPMKNMENGNNGYHKDH VYGIHNPVMTSPSQHTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
