Recombinant Human RPS6KA4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RPS6KA4-2049H
• Product Overview: RPS6KA4 MS Standard C13 and N15-labeled recombinant protein (NP_003933) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 85.4 kDa
• AA Sequence: MGDEDDDESCAVELRITEANLTGHE EKVSVENFELLKVLGTGAYGKVFLV RKAGGHDAGKLYAMKVLRKAALVQR AKTQEHTRTERSVLELVRQAPFLVT LHYAFQTDAKLHLILDYVSGGEMFT HLYQRQYFKEAEVRVYGGEIVLALE HLHKLGIIYRDLKLENVLLDSEGHI VLTDFGLSKEFLTEEKERTFSFCGT IEYMAPEIIRSKTGHGKAVDWWSLG ILLFELLTGASPFTLEGERNTQAEV SRRILKCSPPFPPRIGPVAQDLLQR LLCKDPKKRLGAGPQGAQEVRNHPF FQGLDWVALAARKIPAPFRPQIRSE LDVGNFAEEFTRLEPVYSPPGSPPP GDPRIFQGYSFVAPSILFDHNNAVM TDGLEAPGAGDRPGRAAVARSAMMQ DSPFFQQYELDLREPALGQGSFSVC RRCRQRQSGQEFAVKILSRRLEANT QREVAALRLCQSHPNVVNLHEVHHD QLHTYLVLELLRGGELLEHIRKKRH FSESEASQILRSLVSAVSFMHEEAG VVHRDLKPENILYADDTPGAPVKII DFGFARLRPQSPGVPMQTPCFTLQY AAPELLAQQGYDESCDLWSLGVILY MMLSGQVPFQGASGQGGQSQAAEIM CKIREGRFSLDGEAWQGVSEEAKEL VRGLLTVDPAKRLKLEGLRGSSWLQ DGSARSSPPLRTPDVLESSGPAVRS GLNATFMAFNRGKREGFFLKSVENA PLAKRRKQKLRSATASRRGSPAPAN PGRAPVASKGAPRRANGPLPPSTRT RPLEQKLISEEDLAANDILDYKDDD DKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RPS6KA4 ribosomal protein S6 kinase A4 [ Homo sapiens (human) ]
• Official Symbol: RPS6KA4
• Synonyms: RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; ribosomal protein S6 kinase, 90kD, polypeptide 4; ribosomal protein S6 kinase alpha-4; MSK2; RSK B; RSKB; S6K-alpha-4; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; nuclear mitogen- and stress-activated protein kinase 2; RSK-B
• Gene ID: 8986
• mRNA Refseq: NM_003942
• Protein Refseq: NP_003933
• MIM: 603606
• UniProt ID: O75676