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Recombinant Human S100 Calcium Binding Protein A5

Cat.No. : S100A5-430H
Product Overview : Recombinant HumanS100 Calcium Binding Protein A5 cloned from human cDNA was expressed inE.coli. The protein consists of the human S100A5 (residues 1-92, swissprotaccession P33763). MW = 21.5 kDa (dimer).
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Cat. No. : S100A5-430H
Description : Protein S100-A5 is a protein that in humans is encoded by the S100A5 gene.The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain.
Source : E.Coli.
Purity : > 90% by SDS-PAGE. The protein runs as a monomer giving a single band migrating at a molecular weight < 14 kDa.
Supplied As : 1mg/ml in MES 20mM, NaCl 100 mM, pH 6.5. The concentration is calculated from the absorbance at 280nm (ε280 = 4595 M-1 cm-1).
Characteristics : Under the above described conditions, to avoid precipitation, the product can be concentrated to a maximum of 1.5mM (dimer).
Storage : -20º C. The protein is stable 25 ºC for several hours. After initial defrost, aliquot product into individual tubes and refreeze at -20º C. Avoid repeated freeze/defrost cycles.
Gene Name : S100A5 S100 calcium binding protein A5 [ Homo sapiens ]
Synonyms : S100A5; S100 calcium binding protein A5; S100D; S100A5; Protein S-100D; S100 calcium-binding protein A5; Protein S-100D
Gene ID : 6276
mRNA Refseq : NM_002962
Protein Refseq : NP_002953
MIM : 176991
UniProt ID : P33763
Chromosome Location : 1q21
Function : calcium ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does S100A5 interact with calcium ions and what are the implications of this interaction for cellular signaling? 08/29/2022

S100A5 binds calcium ions, affecting cellular signaling pathways and calcium-dependent processes.

What are the effects of oxidative stress on the function and regulation of S100A5? 01/05/2020

Oxidative stress impacts S100A5 function, affecting its regulatory role in cellular processes.

What role does S100A5 play in the regulation of inflammatory responses and immune cell function? 09/10/2019

S100A5 is involved in regulating inflammation and immune cell function, influencing immune response.

How does S100A5 contribute to neuronal development and neuroplasticity? 06/04/2019

S100A5 plays a role in neuronal development and neuroplasticity, affecting brain function and adaptation.

What is the impact of S100A5 expression on cancer development and progression? 05/28/2019

S100A5 expression influences cancer development, potentially impacting tumor growth and metastasis.

How does S100A5 influence muscle contraction and relaxation mechanisms? 02/24/2019

S100A5 affects muscle contraction and relaxation, playing a role in muscle function and coordination.

How do alterations in S100A5 expression impact cardiovascular health and disease? 01/20/2018

Changes in S100A5 expression can influence cardiovascular health, impacting heart function and disease development.

Customer Reviews (3)

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Reviews
05/07/2020

    Reliable antibody validation, vital for our experiments.

    06/24/2019

      Efficient peptide synthesis, accelerates our peptide research.

      04/25/2018

        Accurate mass spectrometry analysis, crucial for proteomics studies.

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