Recombinant Mouse S100 Calcium Binding Protein A5, His-tagged

Cat.No. : S100a5-5588M
Product Overview : Recombinant mouse S100a5protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
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Cat. No. : S100a5-5588M
Description : S100calcium binding protein A5, also known as S100a5, is a member of the S100 family of proteins containing 2EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasmand nucleus of a wide range of cells, and involved in the regulation of anumber of cellular processes such as cell cycle progression anddifferentiation. S100a5 has a Ca2+ affinity20- to 100-fold higher than the other S100 proteins studied under identicalconditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly whichimpairs the binding of Ca2+. It is expressed in very restricted regions ofthe adult brain.
Form : Liquid. In 20 mMTris-HCl buffer, pH8.0, 40% glycerol, 3mM DTT, 200mM NaCl.
Molecular Weight : 13.4kDa(117aa), confirmed by MALDI-TOF.
Purity : > 95%by SDS-PAGE
Concentration : 1 mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MGSHMETPLE KALTTMVTTF HKYSGREGSK LTLSRKELKE LIKTELSLAEKMKESSIDNL MKSLDKNSDQ EIDFKEYSVF LTTLCMAYND FFLEDNK
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : S100a5 S100 calcium bindingprotein A5 [ Mus musculus ]
Official Symbol : S100a5
Synonyms : S100a5; S100 calcium binding protein A5;S100D9; protein S100-A5; Protein S-100D; S100 calcium-binding protein A5
Gene ID : 20199
mRNA Refseq : NM_011312
Protein Refseq : NP_035442
UniProt ID : P63084
Chromosome Location : 3 F1-F2; 3 43.6 cM
Function : calcium ion binding; copper ion binding;metal ion binding; protein homodimerization activity; zinc ion binding

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Reviews
05/07/2020

    Reliable antibody validation, vital for our experiments.

    06/24/2019

      Efficient peptide synthesis, accelerates our peptide research.

      04/25/2018

        Accurate mass spectrometry analysis, crucial for proteomics studies.

        Q&As (7)

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        How does S100A5 interact with calcium ions and what are the implications of this interaction for cellular signaling? 08/29/2022

        S100A5 binds calcium ions, affecting cellular signaling pathways and calcium-dependent processes.

        What are the effects of oxidative stress on the function and regulation of S100A5? 01/05/2020

        Oxidative stress impacts S100A5 function, affecting its regulatory role in cellular processes.

        What role does S100A5 play in the regulation of inflammatory responses and immune cell function? 09/10/2019

        S100A5 is involved in regulating inflammation and immune cell function, influencing immune response.

        How does S100A5 contribute to neuronal development and neuroplasticity? 06/04/2019

        S100A5 plays a role in neuronal development and neuroplasticity, affecting brain function and adaptation.

        What is the impact of S100A5 expression on cancer development and progression? 05/28/2019

        S100A5 expression influences cancer development, potentially impacting tumor growth and metastasis.

        How does S100A5 influence muscle contraction and relaxation mechanisms? 02/24/2019

        S100A5 affects muscle contraction and relaxation, playing a role in muscle function and coordination.

        How do alterations in S100A5 expression impact cardiovascular health and disease? 01/20/2018

        Changes in S100A5 expression can influence cardiovascular health, impacting heart function and disease development.

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