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Active Recombinant Human S100A12 protein, His-tagged

Cat.No. : S100A12-2563H
Product Overview : Active Recombinant Human S100-A12 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu92) of human S100A12 (Accession #NP_005612.1) fused with a 6×His tag at the C-terminus.
  • Specification
  • Gene Information
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Source : E.coli
Species : Human
Tag : His
Form : Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized Human S100A12 at 2 μg/mL (100 μL/well) can bind recombinant Human AGER/RAGE with a linear range of 0.1-27.25 ng/mL.
Molecular Mass : 10 kDa
Protein Length : Met1-Glu92
Endotoxin : < 0.1 EU/μg of the protein by LAL method.
Purity : > 97% by SDS-PAGE.
Storage : Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution : Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Gene Name : S100A12 S100 calcium binding protein A12 [ Homo sapiens ]
Official Symbol : S100A12
Synonyms : S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; EN-RAGE; calgranulin C; calgranulin-C; neutrophil S100 protein; calcium-binding protein in amniotic fluid 1; S100 calcium-binding protein A12 (calgranulin C); extracellular newly identified RAGE-binding protein;
Gene ID : 6283
mRNA Refseq : NM_005621
Protein Refseq : NP_005612
MIM : 603112
UniProt ID : P80511

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines? 11/30/2022

S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis? 03/16/2022

S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis? 02/23/2022

S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

How does S100A12 contribute to the innate immune response, particularly in bacterial infections? 04/25/2021

S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases? 06/20/2020

Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

How does S100A12 influence calcium signaling and cellular activation in immune cells? 02/20/2020

S100A12 influences calcium signaling in immune cells, affecting their activation and function.

How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation? 01/10/2018

S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.

Customer Reviews (3)

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Reviews
09/30/2022

    Precise protein quantification, fundamental for data accuracy in our experiments.

    03/11/2020

      Timely antibody validation, a valuable asset for our laboratory.

      02/26/2019

        Exceptional protein expression optimization support, greatly enhances our research.

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