S100A12 Protein


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Official Full Name S100 calcium binding protein A12
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
Synonyms S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; Calcitermin; Calcium binding protein in amniotic fluid; Calcium-binding protein in amniotic fluid 1; Calgranulin C; Calgranulin related protein; Calgranulin-C; EN RAGE; EN-RAGE; Extracellular newly identified RAGE binding protein; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; Protein S100 A12; S100 calcium-binding protein A12; S10AC_HUMAN; OTTHUMP00000015332; S100 calcium-binding protein A12 (calgranulin C);
    • Species :
    • Cattle
    • Human
    • Pig
    • Rabbit
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian cells
    • Tag :
    • C-Myc/DDK
    • Fc
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • His(C-ter)
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human S100A12-204H Recombinant Human S100A12, Fc-tagged, C13&N15 Labeled HEK293 Fc Inquiry
    Human S100A12-215H Recombinant Human S100A12, Fc-tagged HEK293 Fc Inquiry
    Human S100A12-2483H Recombinant Human S100A12, GST-tagged E.coli GST Inquiry
    Human S100A12-30229TH Recombinant Human S100A12, His-tagged E.coli His Inquiry
    Human S100A12-3096H Recombinant Human S100A12 protein E.coli N/A Inquiry
    Human S100A12-3721H Recombinant Human S100A12, His-tagged E.coli His Inquiry
    Rabbit S100A12-1480R Recombinant Rabbit S100A12 protein, His & T7-tagged E.coli His/T7 Inquiry
    Cattle S100A12-1478C Recombinant Cattle S100A12 protein, His-tagged E.coli His Inquiry
    Pig S100A12-1479P Recombinant Pig S100A12 protein, His & T7-tagged E.coli His/T7 Inquiry
    Human S100A12-2094HCL Recombinant Human S100A12 293 Cell Lysate HEK293 N/A Inquiry
    Human S100A12-1936H Recombinant Human S100A12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human S100A12-2562H Recombinant Human S100A12 protein, His-tagged E.coli His Inquiry
    Human S100A12-2563H Recombinant Human S100A12 protein, His-tagged E.coli His Inquiry
    Human S100A12-289H Recombinant Human S100A12 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human S100A12-3460H Recombinant Human S100A12 protein, GST-tagged E.coli GST Inquiry
    Human S100A12-653HFL Recombinant Full Length Human S100A12 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human S100A12-063H Recombinant Human S100A12 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK Inquiry
    Human S100A12-2002H Recombinant Human S100A12 Protein, His-tagged E.coli His Inquiry
    Human S100A12-33H Recombinant Human S100A12 protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    S100A12 involved in several pathways and played different roles in them. We selected most pathways S100A12 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling DUSP3; DUSP4; CREB1; SAA1; S100A12; DUSP6; TIRAP; CHST13; DHX9; TICAM1
    Advanced glycosylation endproduct receptor signaling AGER; SAA1; S100A12; S100B; ALCAMB; DDOST; LGALS3; APPB; APPA
    Cytosolic sensors of pathogen-associated DNA IFI16; CRCP; ALCAMB; AGER; TRIM56; POLR3F; NLRP4; APPB; TICAM1; DHX9
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production S100B; APPB; S100A12; APPA; CHST13; DHX9; ALCAMB; SAA1; AGER
    Immune System IFI16; PPIAL4A; KIF26A; IFI27; RNF144B; FBXO17; TXN; BLMH; LTN1; TREML2
    Innate Immune System DHX9; NCKAP1; RCA2.1; CRP; DDX41; GZMM; ALCAMB; CLEC5A; NOD1; PELI1
    MyD88 cascade initiated on plasma membrane DUSP3B; TLR10; S100A12; CHST13; PELI1; AGER; PELI2; PELI3; ALCAMB; TNIP2
    MyD88 dependent cascade initiated on endosome DHX9; ALCAMB; S100B; CHST13; S100A12

    S100A12 has several biochemical functions, for example, RAGE receptor binding, calcium ion binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A12 itself. We selected most functions S100A12 had, and list some proteins which have the same functions with S100A12. You can find most of the proteins on our site.

    Function Related Protein
    RAGE receptor binding HMGB1; FPR1; S100P; S100A4; S100A8; S100A12; S100A9; S100B; S100A7; S100A13
    calcium ion binding EFCAB4A; PCDH2AA3; KIAA0494; COL4A3BPA; CDH6; LDLRB; PCDHB1; PCDH1A3; MAN1B1; PCDH18
    copper ion binding METTL17; ATOX1; LOXL2A; GPC1; COMMD1; AOC3; DCT; PRNPA; TYR; HIST2H3A
    protein binding CBLB; LRRC4B; SOX7; NONO; ANKRD27; HOXA9; ZNF747; ZNF524; FRG1; ICAM1
    zinc ion binding NR2F1A; LMCD1; ADAM1B; WBP4; ZSWIM1; UBOX5; ZNF346; LHX3; ZDHHC20; HNF4G

    S100A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A12.


    Zhan, YC; Zhang, F; et al. Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis. INFLAMMATION 38:290-297(2015).
    Ahmed, U; Thornalley, PJ; et al. Possible role of methylglyoxal and glyoxalase in arthritis. BIOCHEMICAL SOCIETY TRANSACTIONS 42:538-542(2014).

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