S100A12 involved in several pathways and played different roles in them. We selected most pathways S100A12 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Activated TLR4 signalling |
DUSP3; DUSP4; CREB1; SAA1; S100A12; DUSP6; TIRAP; CHST13; DHX9; TICAM1 |
| Advanced glycosylation endproduct receptor signaling |
AGER; SAA1; S100A12; S100B; ALCAMB; DDOST; LGALS3; APPB; APPA |
| Cytosolic sensors of pathogen-associated DNA |
IFI16; CRCP; ALCAMB; AGER; TRIM56; POLR3F; NLRP4; APPB; TICAM1; DHX9 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production |
S100B; APPB; S100A12; APPA; CHST13; DHX9; ALCAMB; SAA1; AGER |
| Immune System |
IFI16; PPIAL4A; KIF26A; IFI27; RNF144B; FBXO17; TXN; BLMH; LTN1; TREML2 |
| Innate Immune System |
DHX9; NCKAP1; RCA2.1; CRP; DDX41; GZMM; ALCAMB; CLEC5A; NOD1; PELI1 |
| MyD88 cascade initiated on plasma membrane |
DUSP3B; TLR10; S100A12; CHST13; PELI1; AGER; PELI2; PELI3; ALCAMB; TNIP2 |
| MyD88 dependent cascade initiated on endosome |
DHX9; ALCAMB; S100B; CHST13; S100A12 |
S100A12 has several biochemical functions, for example, RAGE receptor binding, calcium ion binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A12 itself. We selected most functions S100A12 had, and list some proteins which have the same functions with S100A12. You can find most of the proteins on our site.
| Function |
Related Protein |
| RAGE receptor binding |
HMGB1; FPR1; S100P; S100A4; S100A8; S100A12; S100A9; S100B; S100A7; S100A13 |
| calcium ion binding |
EFCAB4A; PCDH2AA3; KIAA0494; COL4A3BPA; CDH6; LDLRB; PCDHB1; PCDH1A3; MAN1B1; PCDH18 |
| copper ion binding |
METTL17; ATOX1; LOXL2A; GPC1; COMMD1; AOC3; DCT; PRNPA; TYR; HIST2H3A |
| protein binding |
CBLB; LRRC4B; SOX7; NONO; ANKRD27; HOXA9; ZNF747; ZNF524; FRG1; ICAM1 |
| zinc ion binding |
NR2F1A; LMCD1; ADAM1B; WBP4; ZSWIM1; UBOX5; ZNF346; LHX3; ZDHHC20; HNF4G |
S100A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A12.
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Zhan, YC; Zhang, F; et al. Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis. INFLAMMATION 38:290-297(2015).
Ahmed, U; Thornalley, PJ; et al. Possible role of methylglyoxal and glyoxalase in arthritis. BIOCHEMICAL SOCIETY TRANSACTIONS 42:538-542(2014).
