• Official Full Name

    S100 calcium binding protein A12

  • Overview

    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
  • Synonyms

    S100A12; S100 calcium binding protein A12; S100 calcium binding protein A12 (calgranulin C) , S100 calcium binding protein A12 (calgranulin C); protein S100-A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6; Calcitermin; Calcium binding protein in amniotic fluid; Calcium-binding protein in amniotic fluid 1; Calgranulin C; Calgranulin related protein; Calgranulin-C; EN RAGE; EN-RAGE; Extracellular newly identified RAGE binding protein; Extracellular newly identified RAGE-binding protein; Neutrophil S100 protein; Protein S100 A12; S100 calcium-binding protein A12; S10AC_HUMAN; OTTHUMP00000015332; S100 calcium-binding protein A12 (calgranulin C);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Pig
  • Rabbit
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • C
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human S100A12-3096H Active Recombinant Human S100A12 protein(Met1-Glu92) E. coli N/A
Human S100A12-215H Recombinant Human S100A12, Fc-tagged HEK293 Fc
Human S100A12-204H Recombinant Human S100A12, Fc-tagged, C13&N15 Labeled HEK293 Fc
Human S100A12-2483H Recombinant Human S100A12, GST-tagged E.coli GST
Human S100A12-3721H Recombinant Human S100A12, His-tagged E.coli His
Human S100A12-30229TH Recombinant Human S100A12, His-tagged E.coli His
Human S100A12-2094HCL Recombinant Human S100A12 293 Cell Lysate HEK293 N/A
Human S100A12-2002H Recombinant Human S100A12 Protein, His-tagged E.coli His
Human S100A12-063H Recombinant Human S100A12 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human S100A12-2563H Active Recombinant Human S100A12 protein, His-tagged E.coli His
Human S100A12-33H Recombinant Human S100A12 protein, Myc/DDK-tagged HEK293T Myc/DDK
Human S100A12-3460H Recombinant Human S100A12 protein, GST-tagged E.coli GST
Human S100A12-653HFL Recombinant Full Length Human S100A12 Protein, C-Flag-tagged Mammalian cells Flag
Human S100A12-6225H Recombinant Human S100A12 Protein (Met1-Glu92), N-His tagged E.coli N-His
Human S100A12-2562H Active Recombinant Human S100A12 protein, His-tagged E.coli His
Human S100A12-289H Recombinant Human S100A12 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human S100A12-1936H Recombinant Human S100A12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human S100A12-1936H-B Recombinant Human S100A12 Protein Pre-coupled Magnetic Beads HEK293
Rabbit S100A12-1480R Recombinant Rabbit S100A12 protein, His & T7-tagged E.coli His/T7
Cattle S100A12-1478C Recombinant Cattle S100A12 protein, His-tagged E.coli His
Pig S100A12-1479P Recombinant Pig S100A12 protein, His & T7-tagged E.coli His/T7
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • S100A12 Related Articles
  • S100A12 Related Research Area

S100A12 involved in several pathways and played different roles in them. We selected most pathways S100A12 participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Advanced glycosylation endproduct receptor signalingSAA1;S100B;DDOST;AGER;APPA;LGALS3;S100A12;APPB;ALCAMB
Cytosolic sensors of pathogen-associated DNATRIM56;LRRFIP1;TREX1;NLRP4B;NLRP4E;DHX9;POLR3F;CHST13;SAA1
DEx/H-box helicases activate type I IFN and inflammatory cytokines productionS100B;SAA1;APPA;S100A12;AGER;ALCAMB;DHX9;CHST13;APPB
Immune SystemIRF4;ERAP1;GM11711;ICAM4;DEFB4B;DEFB125;ASB13;TRIM6;ASB17
Innate Immune SystemCFD;SIGLEC15;WASF3;MGC174155;BAIAP2;RNF216;MAP3K8;PCBP2;DEFB129
MyD88 cascade initiated on plasma membraneDUSP3B;PELI1;DHX9;AGER;CHST13;S100B;TNIP2;PELI2;PELI3
MyD88 dependent cascade initiated on endosomeDHX9;ALCAMB;S100B;S100A12;CHST13

S100A12 has several biochemical functions, for example, RAGE receptor binding, calcium ion binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A12 itself. We selected most functions S100A12 had, and list some proteins which have the same functions with S100A12. You can find most of the proteins on our site.

Function Related Protein
RAGE receptor bindingS100A8;FPR1;S100A12;S100A13;HMGB1;S100B;S100P;S100A9;HMGB2
calcium ion bindingSMOC2;S100A4;STIM1;PCDH11Y;FKBP9;PCDHA9;PCDHGC5;CPNE6;SCUBE1
copper ion bindingCCS;COX17;SLC11A2;CP;F5;GPC1;TYRP1;POLR1B;LOXL2
protein bindingAGR3;NAA10;NOL6;CTF1;NME2;C14orf166;DCTN3;IGFL1;PRDM10

S100A12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A12 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A12.


Zhan, YC; Zhang, F; et al. Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis. INFLAMMATION 38:290-297(2015).
Ahmed, U; Thornalley, PJ; et al. Possible role of methylglyoxal and glyoxalase in arthritis. BIOCHEMICAL SOCIETY TRANSACTIONS 42:538-542(2014).
  • Q&As
  • Reviews

Q&As (7)

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What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines? 11/30/2022

S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis? 03/16/2022

S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis? 02/23/2022

S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

How does S100A12 contribute to the innate immune response, particularly in bacterial infections? 04/25/2021

S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases? 06/20/2020

Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

How does S100A12 influence calcium signaling and cellular activation in immune cells? 02/20/2020

S100A12 influences calcium signaling in immune cells, affecting their activation and function.

How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation? 01/10/2018

S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.

Customer Reviews (3)

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    Precise protein quantification, fundamental for data accuracy in our experiments.


      Timely antibody validation, a valuable asset for our laboratory.


        Exceptional protein expression optimization support, greatly enhances our research.

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