Recombinant Human S100A12 Protein, His (Fc)-Avi-tagged

• Cat.No.: S100A12-1936H
• Product Overview: Recombinant Human S100A12 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Human
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: S100A12 S100 calcium binding protein A12 [ Homo sapiens (human) ]
• Official Symbol: S100A12
• Synonyms: p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE
• Gene ID: 6283
• mRNA Refseq: NM_005621.2
• Protein Refseq: NP_005612.1
• MIM: 603112
• UniProt ID: P80511

Reviews

09/30/2022

Precise protein quantification, fundamental for data accuracy in our experiments.

03/11/2020

Timely antibody validation, a valuable asset for our laboratory.

02/26/2019

Exceptional protein expression optimization support, greatly enhances our research.

Q&As

What are the mechanisms by which S100A12 modulates the expression of pro-inflammatory cytokines?

S100A12 regulates the production of pro-inflammatory cytokines, impacting the extent and severity of inflammation.

What role does S100A12 play in the pathogenesis of inflammatory diseases like rheumatoid arthritis?

S100A12 is implicated in inflammatory diseases like rheumatoid arthritis, contributing to joint inflammation and damage.

What is the impact of S100A12 on vascular inflammation and the development of atherosclerosis?

S100A12 contributes to vascular inflammation, potentially leading to the development of atherosclerosis.

How does S100A12 contribute to the innate immune response, particularly in bacterial infections?

S100A12 plays a role in the innate immune response against bacterial infections, enhancing pathogen detection and response.

How do alterations in S100A12 expression or function affect chronic inflammatory conditions and autoimmune diseases?

Changes in S100A12 expression can exacerbate chronic inflammatory and autoimmune diseases, affecting disease progression and symptoms.

How does S100A12 influence calcium signaling and cellular activation in immune cells?

S100A12 influences calcium signaling in immune cells, affecting their activation and function.

How does S100A12 (S100 Calcium Binding Protein A12) interact with receptors on immune cells to modulate inflammation?

S100A12 binds to receptors on immune cells, triggering inflammatory responses and modulating immune activity.