Recombinant Human SH2D1A Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | SH2D1A-3239H |
Product Overview : | SH2D1A MS Standard C13 and N15-labeled recombinant protein (NP_002342) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
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Description : | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 14.2 kDa |
AA Sequence : | MDAVAVYHGKISRETGEKLLLATGL DGSYLLRDSESVPGVYCLCVLYHGY IYTYRVSQTETGSWSAETAPGVHKR YFRKIKNLISAFQKPDQGIVIPLQY PVEKKSSARSTQGTTGIREDPDVCL KAPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | SH2D1A SH2 domain containing 1A [ Homo sapiens (human) ] |
Official Symbol : | SH2D1A |
Synonyms : | SH2D1A; SH2 domain containing 1A; IMD5, lymphoproliferative syndrome, LYP, SH2 domain protein 1A; SH2 domain-containing protein 1A; DSHP; Duncans disease; EBVS; MTCP1; SAP; XLP; XLPD; SLAM-associated protein; Duncan disease SH2-protein; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; SLAM associated protein/SH2 domain protein 1A; signaling lymphocyte activation molecule-associated protein; signaling lymphocytic activation molecule-associated protein; LYP; IMD5; SAP/SH2D1A; FLJ18687; FLJ92177; |
Gene ID : | 4068 |
mRNA Refseq : | NM_002351 |
Protein Refseq : | NP_002342 |
MIM : | 300490 |
UniProt ID : | O60880 |
Products Types
◆ Recombinant Protein | ||
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Sh2d1a-5834M | Recombinant Mouse Sh2d1a Protein, Myc/DDK-tagged | +Inquiry |
SH2D1A-22H | Recombinant Human SH2D1A Protein, MYC/DDK-tagged | +Inquiry |
SH2D1A-8116M | Recombinant Mouse SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SH2D1A-1879HCL | Recombinant Human SH2D1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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