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Recombinant Human SMAD7 Protein, MYC/DDK-tagged

Cat.No. : SMAD7-1912H
Product Overview : Recombinant human SMAD7 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
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  • Gene Information
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Description : The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 46.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : SMAD7 SMAD family member 7 [ Homo sapiens ]
Official Symbol : SMAD7
Synonyms : CRCS3; MADH7; MADH8
Gene ID : 4092
mRNA Refseq : NM_001190821
Protein Refseq : NP_001177750
MIM : 602932
UniProt ID : O15105

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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