SMAD7

  • Official Full Name

    SMAD family member 7

  • Overview

    The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    SMAD7; SMAD family member 7; MAD, mothers against decapentaplegic homolog 7 (Drosophila) , MADH7, MADH8, SMAD, mothers against DPP homolog 7 (Drosophila); mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SM;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMAD7-29105TH Recombinant Human SMAD7 Wheat Germ N/A 101 amino acids
Human SMAD7-1912H Recombinant Human SMAD7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SMAD7-561H Recombinant Human SMAD7 protein, His-tagged E.coli His 1-426 aa
Human SMAD7-5871H Recombinant Human SMAD7 Protein (Met1-Arg426), N-His tagged E.coli N-His Met1-Arg426
Human SMAD7-2705H Recombinant Human SMAD7 Protein, His-tagged E.coli N-His Trp261-Arg426
Human SMAD7-241HFL Recombinant Full Length Human SMAD7 Protein, C-Flag-tagged Mammalian cells Flag
Human SMAD7-2043H-B Recombinant Human SMAD7 Protein Pre-coupled Magnetic Beads HEK293
Human SMAD7-2043H Recombinant Human SMAD7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Smad7-5954M Recombinant Mouse Smad7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SMAD7-5610R Recombinant Rat SMAD7 Protein Mammalian Cell His
Rat SMAD7-5269R Recombinant Rat SMAD7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SMAD7-5269R-B Recombinant Rat SMAD7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SMAD7-9566Z Recombinant Zebrafish SMAD7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SMAD7 Related Signal Pathway

SMAD7 involved in several pathways and played different roles in them. We selected most pathways SMAD7 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TGF-beta signaling pathwayACVR2B;ID1;AMHR2;INHBAB;BMP7A;AMH;RPS6KB1B;GDF5;SMAD1
Hippo signaling pathwayYWHAE;CCND3;YWHAH;LLGL1;ITGB2;LATS1;AFP;BMP8A;SMAD7

SMAD7 has several biochemical functions, for example, I-SMAD binding, activin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD7 itself. We selected most functions SMAD7 had, and list some proteins which have the same functions with SMAD7. You can find most of the proteins on our site.

Function Related Protein
I-SMAD bindingAXIN1;CTNNB1;TGFBR1;TGFB1I1;AXIN2;SMAD4;SMAD7;SMAD1;SMAD2
activin bindingENG;FKBP1A;ACVR1;SMURF1;ACVRL1;FST;TGFBR3;FSTL3;ACVR2B
beta-catenin bindingAXIN1;CTNNBIP1;KLF4;TRPC4;GLI3;NF2;PTPRJ;MED12L;CTNNA1
collagen bindingDCN;TLL1;VWF;ADAM9;SERPINH1;ASPN;C1QTNF1;CTSK;MMP13
metal ion bindingMCCC1;ZNF174;DICER1;KLF7B;ARL1;TRIM35-39;METAP2;ATF7;RTEL1
protein bindingZEB1;NAA35;ENOX2;AOC3;GUCY1A3;SPRY4;NDUFAF3;Aatk;EAF2
transcription factor activity, sequence-specific DNA bindingTADA3;HOXB6A;ZIM3;ZIC2;SMAD9;GTF2I;ZC3H8;POU3F2A;THRA
transcription regulatory region DNA bindingKLF17;ERBB4;PROX1;ZNF335;YAP1;H2AFY2;NKX2-1;HIVEP2A;RBBP5
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activitySMAD6;SMAD7
type I transforming growth factor beta receptor bindingSMAD6;SMAD2;TGFBR2;FKBP1A;TGFB3;SMAD7;TGFB1;SNX25;ENG
ubiquitin protein ligase bindingFBXW7;TRAF2;CASP8;NPLOC4;SPOP;FOXO1;HSPA1L;BRCA1;RBX1

SMAD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD7.

COPS5; WWP2; FKBP1A; AXIN1

Gene Family

TGF

Research Area

Related articles

Amiot, A; Peyrin-Biroulet, L; et al. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 8:66-82(2015).
Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).
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