smad7

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smad7

Official Full Name SMAD family member 7
Background The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Synonyms SMAD7; SMAD family member 7; MAD, mothers against decapentaplegic homolog 7 (Drosophila) , MADH7, MADH8, SMAD, mothers against DPP homolog 7 (Drosophila); mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SM
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SMAD7-1912H Recombinant Human SMAD7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SMAD7-29105TH Recombinant Human SMAD7 Wheat Germ N/A
    Human SMAD7-561H Recombinant Human SMAD7 protein, His-tagged E. coli His
    Mouse Smad7-5954M Recombinant Mouse Smad7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat SMAD7-5610R Recombinant Rat SMAD7 Protein Mammalian Cell His
    Zebrafish SMAD7-9566Z Recombinant Zebrafish SMAD7 Mammalian Cell His

    smad7 involved in several pathways and played different roles in them. We selected most pathways smad7 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with smad7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway CHD; RHOAD; LFT1; ID2; ACVR2AA; RHOA; TFDP1A; FSTA; BMP8B; CUL1B
    Hippo signaling pathway WNT2B; WNT16; TCF7; AXIN1; GDF5; YWHAH; TEAD3; Fzd4; LLGL1; FZD2

    smad7 has several biochemical functions, for example, I-SMAD binding, activin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by smad7 itself. We selected most functions smad7 had, and list some proteins which have the same functions with smad7. You can find most of the proteins on our site.

    Function Related Protein
    I-SMAD binding SMAD4; SMAD2; SMAD7; TGFBR1; AXIN1; AXIN2; SMAD1; TGFB1I1; SMAD6; CTNNB1
    activin binding SMAD7; ENG; FST; ACVRL1; ACVR1; SMURF1; ACVR2B; FKBP1A; FSTL3; TGFBR3
    beta-catenin binding TBL1X; TCF7L2; PTBP3; SOX17; DVL3; Ar; PROP1; LZTS2A; GRIP1; TCF7L1A
    collagen binding DDR1; SMAD3; SERPINH2; TGFBI; PODN; CTSS; MMP13; ITGA10; CD44; NID1
    metal ion binding CHPF; DMRTC2; NENF; CYP2X8; ZFP423; ZFP746; ROR2; ZNF254; TRIM55B; IREB2
    protein binding MPZL3; SNRPF; EEF1A2; ZNF238; PUF60; SERPINF1; EIF3G; SPIN1; UBA1; ZMYM4
    transcription factor activity, sequence-specific DNA binding SALL1A; TFAP2C; HIVEP2A; VED; SIM1A; DMRT2; TAF1B; MESPBA; ZNF7; HNF4G
    transcription regulatory region DNA binding ARID5A; BCL11B; REST; CDK5RAP2; FOXM1; ZFP161; RFX6; DLX5; SOX17; GABPA
    transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity SMAD7; SMAD6
    type I transforming growth factor beta receptor binding SNX25; SMAD7; TGFB1; ENG; TGFBR2; FKBP1A; SMAD2; TGFB3; SMAD6
    ubiquitin protein ligase binding LC3; CUL4A; Fzd4; PER1; SMC6; UBE2V2; OTUB1; CUL3; CUL9; UBE2C

    smad7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with smad7 here. Most of them are supplied by our site. Hope this information will be useful for your research of smad7.

    COPS5; WWP2; FKBP1A; AXIN1

    Amiot, A; Peyrin-Biroulet, L; et al. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 8:66-82(2015).
    Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).

    TGF

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