SMAD7 Protein

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SMAD7

Official Full Name	SMAD family member 7
Background	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Synonyms	SMAD7; SMAD family member 7; MAD, mothers against decapentaplegic homolog 7 (Drosophila) , MADH7, MADH8, SMAD, mothers against DPP homolog 7 (Drosophila); mothers against decapentaplegic homolog 7; hSMAD7; MAD homolog 8; mothers against DPP homolog 8; SM

Type:
Recombinant Proteins

Species :
Human
Mouse
Rat
Zebrafish

Source :
E. coli
E.coli
HEK293
HEK293T
Mammalian Cell
Mammalian cells
Wheat Germ

Tag :
Flag
His
Myc/DDK
Myc
DDK
N/A
N-His

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	SMAD7-29105TH	Recombinant Human SMAD7	Wheat Germ	N/A	Inquiry
Rat	SMAD7-5610R	Recombinant Rat SMAD7 Protein	Mammalian Cell	His	Inquiry
Zebrafish	SMAD7-9566Z	Recombinant Zebrafish SMAD7	Mammalian Cell	His	Inquiry
Human	SMAD7-241HFL	Recombinant Full Length Human SMAD7 Protein, C-Flag-tagged	Mammalian cells	Flag	Inquiry
Human	SMAD7-2705H	Recombinant Human SMAD7 Protein, His-tagged	E.coli	N-His	Inquiry
Human	SMAD7-1912H	Recombinant Human SMAD7 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	SMAD7-561H	Recombinant Human SMAD7 protein, His-tagged	E. coli	His	Inquiry
Mouse	Smad7-5954M	Recombinant Mouse Smad7 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry

Involved Pathway Protein Function Interacting Protein SMAD7 Related Articles SMAD7 Related Gene Family

SMAD7 involved in several pathways and played different roles in them. We selected most pathways SMAD7 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
TGF-beta signaling pathway	BMPR1A; BMP7A; SMAD3; RPS6KB1; LEFTY1; NOG; CHD; RPS6KB2; TGFBR1; BMPR1B
Hippo signaling pathway	TCF7; PPP2R2C; SERPINE1; PPP2CA; JUB; CTNNA2; BMP6; FRMD6; DVL3; BMP8A

SMAD7 has several biochemical functions, for example, I-SMAD binding, activin binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD7 itself. We selected most functions SMAD7 had, and list some proteins which have the same functions with SMAD7. You can find most of the proteins on our site.

Function	Related Protein
I-SMAD binding	SMAD1; CTNNB1; SMAD4; AXIN1; SMAD2; SMAD6; AXIN2; TGFB1I1; SMURF1; SMAD7
activin binding	TGFBR3; FKBP1A; ACVRL1; SMURF1; SMAD7; ENG; ACVR1; ACVR2B; FST; FSTL3
beta-catenin binding	GRIP1; CDH2; C; CTNNA3; SMAD7; CDH24; ASH2L; VCL; LZTS2A; TCF7L1A
collagen binding	CTSK; SERPINH1A; COMP; LRRC15; HSD17B12; MTAP1A; VWF; SERPINH2; Itga10&Itgb1; ANTXR1
metal ion binding	POLR3B; RC3H2; GFI1AA; ZNF823; FEZF1; CYP3C1L2; CACNA2D4; LNX2B; ATP2B2; TRIM71
protein binding	ACAD9; SNRPA; EVI5; RTN4A; TRIM59; CCDC64B; RPL7A; BCL2; HOXA10; TNFAIP8L2
transcription factor activity, sequence-specific DNA binding	HOXD4A; CTNNB1; NEUROD1; TFE3; CREB3L3L; DMRT2; NKX3-1; ZKSCAN1; GATAD2B; ZFP110
transcription regulatory region DNA binding	MLL1; BASP1; MTERFD3; FOS; ARRB1; ASH2L; WNT1; H2AFY2; DLX5; TP63
transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity	SMAD6; SMAD7
type I transforming growth factor beta receptor binding	SNX25; SMAD2; ENG; TGFB1; TGFB3; TGFBR2; SMAD6; FKBP1A; SMAD7
ubiquitin protein ligase binding	NDUFS2; PPARGC1A; PACRG; CD40; CASP8; ANAPC2; DNAJA1; TRAF6; JKAMP; MAGEC2

SMAD7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD7 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD7.

COPS5; WWP2; FKBP1A; AXIN1

Amiot, A; Peyrin-Biroulet, L; et al. Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases. THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 8:66-82(2015).

Li, TT; Zhang, XH; et al. Artemisinin analogue SM934 ameliorates the proteinuria and renal fibrosis in rat experimental membranous nephropathy. ACTA PHARMACOLOGICA SINICA 36:188-199(2015).