| Species : |
Human |
| Source : |
E.coli |
| Tag : |
Non |
| Description : |
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. |
| Tissue specificity : |
Expressed in goblet cells of the intestines and colon (at protein level). Expressed by goblet cells of small and large intestinal epithelia and also by the uterus. |
| Biological activity : |
Biological Activity : Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 μg/ml. |
| Form : |
Lyophilised:Centrifuge the vial prior to opening. Reconstitute in waterto a concentration of 0.1-1.0 mg/ml. Do not vortex. Thissolution can be stored at 2-8°C for up to 1 week. Forextended storage, it is recommended to further dilute in abuffer containing |
| Purity : |
>95% by SDS-PAGE |
| Storage : |
The lyophilized protein is stable at room temperature for up to 1 month. Working aliquots stored with a carrier protein are stable for at least 3 months at -20°C to -80°C. Avoid repeated freeze/thaw cycles. See reconstitution notes |
| Sequences of amino acids : |
EEYVGLSANQ CAVPAKDRVD CGYPHVTPKE CNNRGCCFDS RIPGVPWCFK PLQEAECTF |
| Sequence Similarities : |
Contains 1 P-type (trefoil) domain. |
