Recombinant Human TNFRSF1B
Cat.No. : | TNFRSF1B-180H |
Product Overview : | Recombinant human sTNFRII produced inE.coliis an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein. |
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Cat. No. : | TNFRSF1B-180H |
Description : | TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. |
Source : | E.coli. |
Purity : | > 98% by SDS-PAGE and HPLC analyses. |
Endotoxin Level : | < 0.1 ng per ug of sTNF-receptor. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biological Activity : | Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.125 μg/ml. |
Reconstitution : | We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/ml. This solution can be diluted into other aqueous buffers and stored at -20℃ for future use. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted sTNFRII is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles. |
Tag : | Non |
Gene Name : | TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ] |
Synonyms : | TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; Tumour necrosis factor receptor 2; Tumour receptor beta receptor; Tumour necrosis factor binding protein 2; Tumour necrosis factor receptor superfamily member 1B; Tumour necrosis factor receptor type II; p80 TNF alpha; receptor; Etanercept; CD120b; p75; TBPII; TNFRII, TNFR75; TNFBR; TNFR2; TNFR80; TNFR1B; TNF-R75; p75TNFR; TNF-R-II; TNFRSF1B; p75 TNF receptor; OTTHUMP00000001784; soluble TNFR1B variant 1; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; TNF-R2; CD120b antigen |
Gene ID : | 7133 |
mRNA Refseq : | NM_001066 |
Protein Refseq : | NP_001057 |
MIM : | 191191 |
UniProt ID : | P20333 |
Chromosome Location : | 1p36.3-p36.2 |
Function : | protein binding; receptor activity; tumor necrosis factor receptor activity |
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