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Recombinant Human TNFRSF9

Cat.No. : TNFRSF9-110H
Product Overview : Recombinant Human 4-1BB Soluble Receptor also called Tumor necrosis factor receptor superfamily member 9 produced inE.Coliis a single, non-glycosylated polypeptide chain containing 167 amino acids, having a molecular mass of 17718 Dalton and containing the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. The expression of this receptor is induced by lymphocyte activation. The 4-1BB Receptor is purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : TNFRSF9-110H
Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.
Solubility : It is recommended to reconstitute the lyophilized 4-1BB Receptor in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Arg-Thr-Arg.
Biological Activity : The activity was determined by the inhibition of 4-1BB ligand mediated stimulation of IL-8 production by human PBMC. Results: 90% inhibition using 1µg for both 4-1BB ligand and 4-1BB receptor.
Storage : Lyophilized 4-1BB Receptor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4-1BBR should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : TNFRSF9 tumor necrosis factor receptor superfamily, member 9 [ Homo sapiens ]
Synonyms : Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor T-cell; antigen 4-1BB homolog; T-cell antigen ILA; CD137 antigen; MGC2172; 4-1BBR;TNFRSF9; CD137; CDw137; ILA; OTTHUMP00000001360; OTTHUMP00000044294; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; T-cell antigen 4-1BB homolog; 4-1BB
Gene ID : 3604
mRNA Refseq : NM_001561
Protein Refseq : NP_001552
MIM : 602250
UniProt ID : Q07011
Chromosome Location : 1p36
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What diseases are associated with abnormal expression levels of TNFRSF9? 12/10/2022

Studies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.

What is the association of TNFRSF9 with other cytokines? 10/27/2022

It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.

What are the main functions of TNFRSF9 in the human body? 07/11/2022

TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.

Are there potential therapeutic applications for TNFRSF9 inhibitors or activators? 08/21/2021

Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.

How does TNFRSF9 bind to its ligands? 06/08/2021

The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.

How is TNFRSF9 related to immuno-oncology? 05/27/2020

TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.

Customer Reviews (3)

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Reviews
03/11/2022

    Good heat resistance, long time treatment at high temperature, still has activity.

    10/11/2021

      The results obtained by SDS-PAGE or Western blot analysis were good.

      07/30/2021

        The purity is good, and the experimental results obtained are accurate.

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