Recombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a)
Cat.No. : | CXCL12-391M |
Product Overview : | Recombinant Mouse Stromal Cell-Derived Factor-1 alpha produced inE.Coliis a non-glycosylated, Polypeptide chain containing 68 amino acids and having a molecular mass of 7921 Dalton. The SDF-1a is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Cat. No. : | CXCL12-391M |
Description : | SDF-1 (stromal cell-derived factor-1) is small cytokine belonging to the chemokine family that is officially designated Chemokine (C-X-C motif) ligand 12 (CXCL12). It is produced in two forms, SDF-1α/CXCL12a and SDF-1β/CXCL12b, by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines, which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines, whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. |
Source : | Escherichia Coli. |
Amino Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Lys-Pro-Val-Ser-Leu. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized Stromal Cell-Derived Factor-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Purity : | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Biological Activity : | The specific activity as determined by its ability to chemoattract human peripheral blood monocytes at 50-100 ng/ml. |
Formulation : | The CXCL12 protein was lyophilized from a concentrated (1 mg/ml) sterile solution containing 10mM acetic acid (AcOH). |
Stability : | Lyophilized SDF-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL12 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | Cxcl12 chemokine (C-X-C motif) ligand 12 [ Mus musculus ] |
Synonyms : | CXCL12; PBSF; SCYB12; SDF-1a; SDF-1b; SDF1; SDF1A; SDF1B; TLSF-a; TLSF-b; TPAR1; chemokine (C-X-C motif) ligand 12; Sdf1; TLSF; SDF-1; Sdf1a; Sdf1b; TPAR1; Scyb12; AI174028; PBSF/SDF-1; Cxcl12; stromal cell derived factor 1; stromal cell derived factor 1;OTTMUSP00000026112; OTTMUSP00000026113; OTTMUSP00000026114; pre-B-cell growth-stimulating factor; OTTHUMP00000019491; hIRH; C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); stromal cell-derived factor 1; stromal cell-derived factor 1 delta; stromal cell-derived factor 1 gamma; stromal cell-derived factor 1a |
Gene ID : | 20315 |
mRNA Refseq : | NM_001012477 |
Protein Refseq : | NP_001012495 |
UniProt ID : | P40224 |
Chromosome Location : | 6 F1; 6 53.0 cM |
Pathway : | Axon guidance; Cytokine-cytokine receptor interaction; Leukocyte transendothelial migration |
Function : | Chemokine activity; cytokine activity; growth factor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.
Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.
CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.
Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.
Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.
Customer Reviews (3)
Write a reviewThe CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.
Its purity and integrity have consistently delivered reliable and robust results in my research.
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