Active Recombinant Human CXCL12, biotinylated
Cat.No. : | CXCL12-133H |
Product Overview : | Recombinant human CXCL12a is produced in E. coli, biotinylated. Biotinylated enzymatically at the last lysine in the sequence. |
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Description : | CXCL12a and CXCL12b, also known as Stromal Cell-Derived Factor 1α and 1β (SDF-1α and SDF-1β), are small cytokines that belong to the intercrine family. Both forms of CXCL12 are produced by alternate splicing of the same gene. |
Source : | E. coli |
Species : | Human |
Tag : | Biotin |
Form : | Lyophilized. |
Bio-activity : | EC50 = 2.5nm determined by Calcium Flux with recombinant human CXCR4 cells. Migration confirmed with U937 cells expressing CXCR4. |
Molecular Mass : | 10.4kDa by Mass Spec. |
AA Sequence : | KPVSLSYRCPCRFFESHVARANVKH LKILNTPNCALQIVARLKNNNRQVC IDPKLKWIQEYLEKALNKKLGSGLN DIFEAQKIEWHE |
Endotoxin : | <0.01 EU per 1ug of protein by LAL method. |
Purity : | >97% by SDS-PAGE |
Storage : | 12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution. |
Reconstitution : | Recommended at 100ug/ml in sterile distilled water. |
Gene Name : | CXCL12 chemokine (C-X-C motif) ligand 12 [ Homo sapiens ] |
Official Symbol : | CXCL12 |
Synonyms : | CXCL12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); SF; SCYB12; SDF-1a; SDF-1b; SDF1; SDF-1; SDF1A; SDF1B; TLSF; TLSF-a; TLSF-b; TPAR1; C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; Stromal cell-derived factor 1 precursor; tromal cell-derived factor 1; stromal cell-derived factor 1 delta; stromal cell-derived factor 1 gamma; stromal cell-derived factor 1a |
Gene ID : | 6387 |
mRNA Refseq : | NM_199168 |
Protein Refseq : | NP_954637 |
MIM : | 600835 |
UniProt ID : | P48061 |
Chromosome Location : | 10q11 |
Pathway : | CXCR4-mediated signaling events; Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; GPCR downstream signaling; HIF-1-alpha transcription factor network; |
Function : | chemokine activity; emokine activity; growth factor activity; signal transducer activity; receptor binding; CXCR chemokine receptor binding |
Products Types
◆ Recombinant Protein | ||
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Cxcl12-208C | Active Recombinant Mouse Cxcl12 Protein (68 aa) | +Inquiry |
CXCL12-4351R | Recombinant Rabbit CXCL12 Protein | +Inquiry |
CXCL12-033H | Recombinant Human CXCL12 Protein, Biotinylated | +Inquiry |
◆ Lysates | ||
CXCL12-3016HCL | Recombinant Human CXCL12 cell lysate | +Inquiry |
CXCL12-1863CCL | Recombinant Cynomolgus CXCL12 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.
Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.
CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.
Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.
Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.
Customer Reviews (3)
Write a reviewThe CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.
Its purity and integrity have consistently delivered reliable and robust results in my research.
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