Recombinant Mouse CLEC4E Protein (46-214 aa), His-tagged

• Cat.No.: CLEC4E-2057M
• Product Overview: Recombinant Mouse CLEC4E Protein (46-214 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Immunology. Protein Description: Partial.

Specification

• Description: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 23.6 kDa
• Protein length: 46-214 aa
• AA Sequence: TYRSSQISGQNLQPHRNIKELSCYS EASGSVKNCCPLNWKHYQSSCYFFS TTTLTWSSSLKNCSDMGAHLVVIDT QEEQEFLFRTKPKRKEFYIGLTDQV VEGQWQWVDDTPFTESLSFWDAGEP NNIVLVEDCATIRDSSNSRKNWNDI PCFYSMPWICEMPEISPLD
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Clec4e C-type lectin domain family 4, member e [ Mus musculus ]
• Official Symbol: CLEC4E
• Synonyms: CLEC4E; C86253; Mincle; Clecsf9
• Gene ID: 56619
• mRNA Refseq: NM_019948
• Protein Refseq: NP_064332
• UniProt ID: Q9R0Q8