| Description : |
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. |
| Source : |
E. coli |
| Species : |
Mouse |
| Form : |
Lyophilized freeze dried protein without additives. |
| Bio-activity : |
The activity was determined by the stimulation of HUVE cells. The ED50 for this effect is = 0.1 ng/mL corresponding to a specific activity of = 1 × 10^7 units/mg. |
| Molecular Mass : |
16.34 kDa |
| AA Sequence : |
ALPEDGGAAFPPGHFKDPKRLYCKN GGFFLRIHPDGRVDGVREKSDPHVK LQLQAEERGVVSIKGVCANRYLAMK EDGRLLASKCVTEECFFFERLESNN YNTYRSRKYSSWYVALKRTGQYKLG SKGPGQKAILFLPMSAKSResultb yN-terminalsequencing:ALPEDGGAAF |
| Endotoxin : |
< 0.1 ng/μg of Mouse FGF-2 |
| Purity : |
> 95 % |
| Storage : |
The lyophilized Mouse FGF-2, though stable at room temperature, is best stored in working aliquots at –20 to –70 centigrade.
Avoid repeated freeze-thaw cycles |
| Storage Buffer : |
PBS without stabilizers |
| Reconstitution : |
Restore with ddH2O or 50 mM Acetic Acid at 50 μg/mL. This solution can be diluted into other buffered solutions or stored frozen for future use. |
