Active Recombinant Human FGF2
Cat.No. : | FGF2-169H |
Product Overview : | Fibroblast Growth Factor-2 Human Recombinant (FGF-2) produced in Sf9 insect cells is a single, glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of 17353 Dalton. The FGF-basic is purified by proprietary chromatographic techniques. |
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Description : | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. |
Source : | Baculovirus |
Species : | Human |
Form : | Sterile Filtered liquid formulation. The sterile protein solution (0.5mg/ml) contains 20mM Tris pH=7.9, 100mM KCl, 1mM DTT and 20% glycerol. |
Bio-activity : | The ED50, calculated by the dose-dependant proliferation of BAF3 cells expressing FGF receptors (measured by 3H-thymidine uptake) is<0.5 ng/ml, corresponding to a specific activity of>0.5> |
Molecular Mass : | 17353 Dalton |
AA Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ala-Gly-Ser-Ile. |
Purity : | Greater than 98.0% as determined by RP-HPLC and SDS-PAGE. |
Stability : | Fibroblast Growth Factor-basic although stable at 4oC for 3 weeks, should be stored desiccated below -18oC. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Tag : | Non |
Gene Name : | FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens (human) ] |
Official Symbol : | FGF2 |
Synonyms : | FGF2; fibroblast growth factor 2 (basic); BFGF; FGFB; HBGF-2; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor Bfgf; Basic fibroblast growth factor |
Gene ID : | 2247 |
mRNA Refseq : | NM_002006 |
Protein Refseq : | NP_001997 |
MIM : | 134920 |
UniProt ID : | P09038 |
Chromosome Location : | 4q26 |
Pathway : | MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; aling by FGFR; SHC-mediated cascade; Syndecan-4-mediated signaling events; |
Function : | growth factor activity; heparin binding; protein binding; voltage-gated calcium channel activity; ligand-dependent nuclear receptor transcription coactivator activity; protein tyrosine kinas activity |
Products Types
◆ Recombinant Protein | ||
FGF2-1429H | Recombinant Human FGF2 protein | +Inquiry |
Fgf2-7206M | Active Recombinant Mouse Fgf2 Protein | +Inquiry |
FGF2-400F | Active Recombinant Human FGF2 Protein (154 aa) | +Inquiry |
FGF2-044H | Active Recombinant Human FGF2 Protein | +Inquiry |
FGF2-1967R | Recombinant Rat FGF2 Protein | +Inquiry |
◆ Native Protein | ||
FGF2-34B | Active Native Bovine bFGF | +Inquiry |
FGF2-26551TH | Native Human FGF2 | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (2)
Write a reviewThe technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.
The purchased protein is suitable for WB experiments and I am satisfied with the results.
Q&As (6)
Ask a questionFGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.
FGF2 is widely expressed in the nervous system.
FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.
FGF1 has a high degree of homology with FGF2.
FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.
FGF2 negatively regulates bone homeostasis.
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