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Active Recombinant Mouse Ifng Protein

Cat.No. : Ifng-077M
Product Overview : Purified recombinant protein of Mouse interferon gamma (Ifng) (His23-Cys155) without tag was expressed in E.coli.
  • Specification
  • Gene Information
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Description : This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mice deficient in this gene have increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases.
Source : E. coli
Species : Mouse
Bio-activity : The ED50 is 0.2-0.6 ng/ml, corresponding to a specific activity of 5 - 1.67 x 10^6 units/mg, determined by inhibition of WEHI-279 cell proliferation induced by mouse IFNγ.
Molecular Mass : 15.7 kDa
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method
Purity : >98%, as determined by Coomassie stained SDS-PAGE.
Stability : Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Storage : Store at -80 centigrade.
Concentration : Protein formulated and vialed at >50 ug/mL in specified buffer
Storage Buffer : 20 mM HEPES, 150 mM NaCl, 5 mM TCEP; pH7.2
Gene Name : Ifng interferon gamma [ Mus musculus (house mouse) ]
Official Symbol : Ifng
Synonyms : Ifng; interferon gamma; Ifg; IFN-g; interferon gamma; IFN-gamma; gamma interferon
Gene ID : 15978
mRNA Refseq : NM_008337
Protein Refseq : NP_032363
UniProt ID : P01580

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the role of IFNG in tumor immunotherapy? 09/23/2022

IFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.

What is the current progress in drug development for IFNG? 12/19/2021

The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.

How is IFNG related to muscle wasting? 12/02/2021

Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.

How can IFNG be used as a biomarker in clinical practice? 03/01/2021

In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.

Are there other coding variants in the IFNG gene? 07/12/2020

Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.

Is the expression of IFNG affected by environmental factors? 05/26/2020

Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.

Customer Reviews (3)

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Reviews
12/17/2022

    It is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.

    06/10/2022

      Easy to attach to the surface of cells or materials.

      04/02/2022

        IFNG products have a complete range of specifications for experimental designs of different sizes and needs.

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