| Description : |
This gene encodes a a pleiotropic cytokine of the interleukin family of proteins that plays important roles in the innate and adaptive cell homeostasis, as well as peripheral immune function. The encoded protein undergoes proteolytic processing to generate a mature cytokine that stimulates the proliferation of natural killer cells. The transgenic mice overexpressing the encoded protein exhibit an increase in the number of memory CD8+ T cells in a naive state and enhanced protection against bacterial infections. Mice lacking the encoded protein exhibit impaired protection against a strain of attenuated Mycobacterium. |
| Source : |
E. coli |
| Species : |
Mouse |
| Bio-activity : |
The ED50 was determined by the stimulation of the proliferation of murine CTLL-2 cells is > 5.0 ng/ml, corresponding to a specific activity of > 2 x 10^5 units/mg. |
| Molecular Mass : |
13.3 kDa |
| AA Sequence : |
MNWIDVRYDLEKIESLIQSIHIDTT LYTDSDFHPSCKVTAMNCFLLELQV ILHEYSNMTLNETVRNVLYLANSTL SSNKNVAESGCKECEELEEKTFTEF LQSFIRIVQMFINTS |
| Endotoxin : |
Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg) |
| Purity : |
>95%, as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. |
| Storage Buffer : |
Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2 |
| Reconstitution : |
Resuspend the protein in the desired concentration in proper buffer. |
