Recombinant Human IL15 protein
Cat.No. : | IL15-321H |
Product Overview : | Recombinant Human IL15 protein (Asn49-Ser162) carries no tag and was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health. |
Source : | HEK293 |
Species : | Human |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | 114 |
Endotoxin : | Less than 0.1 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL15 |
Official Symbol : | IL15 |
Synonyms : | IL15; interleukin 15; interleukin-15; IL 15; MGC9721; IL-15 |
Gene ID : | 3600 |
mRNA Refseq : | NM_000585 |
Protein Refseq : | NP_000576 |
MIM : | 600554 |
UniProt ID : | P40933 |
Products Types
◆ Recombinant Protein | ||
IL15-2053R | Recombinant Rhesus Macaque IL15 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL15-370I | Active Recombinant Human IL15 Protein (121 aa), His-tagged | +Inquiry |
IL15-01R | Recombinant Rhesus Monkey IL15 Protein, His-tagged | +Inquiry |
Il15-146M | Recombinant Active Mouse IL15 Protein, His-tagged(N-ter) | +Inquiry |
IL15-063H | Active Recombinant Human IL15 Protein | +Inquiry |
◆ Lysates | ||
IL15-5248HCL | Recombinant Human IL15 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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