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IL15

  • Official Full Name

    interleukin 15

  • Overview

    Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
  • Synonyms

    IL15; MGC9721; Interleukin-15 precursor; OTTHUMP00000164617; interleukin 15; IL-15;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus / Rhesus macaque
  • Equine
  • Feline
  • Goat
  • Guinea pig
  • Guinea Pig
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Rhesus Monkey
  • Sheep
  • Zebrafish
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Human Cells
  • Mammalian Cell
  • Mouse
  • Sf21 Insect Cell
  • Yeast
  • C
  • His
  • DYKDDDDK
  • Fc
  • Avi
  • hFc
  • Myc
  • His (Fc)
  • His(N
  • ter)
  • His|S
  • human|IgG1|Fc
  • DDK
  • MYC
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL15-330H Active Recombinant Human IL15, Fc-tagged CHO Fc
Human IL15-306H Active Recombinant Human IL15 protein, His-tagged E.coli His Asn49-Ser162
Human IL15-25H Active Recombinant Human IL15 E.coli N/A
Human Il15-001H Active Recombinant Human Il15, HIgG1 Fc-tagged, mutant CHO Fc
Human IL15-006H Active Recombinant Human IL15, HIgG1 Fc-tagged CHO Fc
Human Il15-002H Active Recombinant Human Il15, MIgG2a Fc-tagged CHO Fc
Human IL15-483H Active Recombinant Human Interleukin 15 E.coli N/A
Human IL15-271H Active Recombinant Human IL15 protein HEK293 N/A Asn 49 - Ser 162
Human IL15-2177H Active Recombinant Human IL15 protein, His-tagged HEK293 His Asn 49 - Ser 162
Human IL15-01HG Active GMP Recombinant Human IL15 Protein CHO-K1
Human IL15-24H Recombinant Human IL15 protein E.coli N/A 114
Human IL15-28238TH Recombinant Human IL15, His-tagged E.coli His
Human IL15-125H Recombinant Human IL15 protein E.coli N/A
Human IL15-004H Active Recombinant Human IL15 Protein, His-tagged E.coli His
Human IL15-270H Recombinant Human IL15, StrepII-tagged Human Cell Strep II 30-162, 133 a.a.
Human IL15-5248HCL Recombinant Human IL15 293 Cell Lysate HEK293 N/A
Human IL15-147H Human Interleukin-15(rDNA derived) Reference standard N/A
Human IL15-382H Active Recombinant Human IL15 protein(Asn49-Ser162) E.coli N/A Asn49-Ser162
Human IL15-5922H Recombinant Human IL15 protein, hFc-Myc-tagged HEK293 hFc-Myc 49-162aa
Human IL15-272H Active Recombinant Human IL15 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Asn49-Ser162
Human IL15-26H Active Recombinant Human IL15 Protein, Animal Free Human cells
Human IL15-6361H Recombinant Human IL15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IL15-4329HG GMP Recombinant Human IL15 protein E.coli N/A 114
Human IL15-321H Recombinant Human IL15 protein HEK293 114
Human IL15-05HG Active Recombinant Human IL15 Protein (Asn49-Ser162), GMP Grade, Animal-Free E.coli Asn49-Ser162
Human IL15-151H Recombinant Human IL15 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human IL15-336HG Active GMP Recombinant Human IL15 Protein E.coli
Human IL15-507H Recombinant Human IL15 Protein 291
Human IL15-337HG Active GMP Recombinant Human IL15 protein CHO
Human IL15-100H Active Recombinant Human IL15 Protein E.coli Asn49-Ser162
Human IL15-145H Recombinant Active Human IL15 Protein, His-tagged(N-ter) E.coli His(N-ter)
Human IL15-21HG Active Recombinant Human IL15 Protein (Asn49-Ser162), GMP Grade, Animal-Free E.coli Asn49-Ser162
Human IL15-063H Active Recombinant Human IL15 Protein E.coli
Human IL15-35HG Recombinant Human IL15 Protein, GMP Grade, Animal-Free E.coli
Human IL15-134H Active Recombinant Human IL15 Protein E.coli
Human IL15-0176H Active Recombinant Human IL15 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Asn49-Ser162
Human IL15-2473H Recombinant Human IL15 Protein (Met21-Gly133), His tagged E.coli His Met21-Gly133
Human IL15-2474H Recombinant Human IL15 Protein (Asn49-Ser162), C-His tagged E.coli C-His Asn49-Ser162
Human IL15-369I Active Recombinant Human IL15 Protein (114 aa) E.coli 114
Human IL15-150H Recombinant Human IL15 Protein, Mature chain, Tag Free, Biotinylated HEK293 Tag Free Mature chain
Human IL15-370I Active Recombinant Human IL15 Protein (121 aa), His-tagged E.coli His 121
Human IL15-180H Active Recombinant Human IL15 Protein (Asn49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli N-His Asn49-Ser162
Mouse Il15-484M Active Recombinant Mouse Interleukin 15 E.coli N/A
Mouse Il15-739M Active Recombinant Mouse Interleukin 15, His-tagged E.coli His 49-162aa
Mouse Il15-423M Active Recombinant Mouse Interleukin 15, His-tagged Mouse His
Mouse Il15-533M Active Recombinant Mouse Interleukin 15, His-tagged Mouse His
Mouse Il15-01M Active Recombinant Mouse Il15 Protein, His-Tagged E.coli His
Mouse Il15-69M Recombinant Mouse Interleukin 15 E.coli N/A
Mouse IL15-8119M Recombinant Mouse IL15 Protein Mammalian Cell His
Mouse Il15-7234M Active Recombinant Mouse Il15 Protein, His-tagged E.coli His
Mouse IL15-4494M-B Recombinant Mouse IL15 Protein Pre-coupled Magnetic Beads HEK293
Mouse IL15-0178M Active Recombinant Mouse IL15 protein, Fc-tagged HEK293 Fc Asn49-Ser162
Mouse Il15-50M Active Recombinant Mouse Il15 Protein (Asn49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli N-His Asn49-Ser162
Mouse IL15-4494M Recombinant Mouse IL15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IL15-0179M Active Recombinant Mouse IL15 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Asn49-Ser162
Mouse Il15-146M Recombinant Active Mouse IL15 Protein, His-tagged(N-ter) E.coli His(N-ter)
Mouse Il15-647M Recombinant Mouse Il15 protein, Fc-tagged HEK293 human/IgG1/Fc Asn49-Ser162
Mouse Il15-091M Active Recombinant Mouse Il15 Protein E.coli
Mouse Il15-092M Recombinant Mouse Il15 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat IL15-3028R Recombinant Rat IL15 Protein Mammalian Cell His
Rat Il15-231R Recombinant Rat Interleukin 15 Sf21 Insect Cell N/A
Rat Il15-88R Recombinant Rat Interleukin 15 E.coli N/A
Rat IL15-2683R-B Recombinant Rat IL15 Protein Pre-coupled Magnetic Beads HEK293
Rat IL15-2683R Recombinant Rat IL15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Monkey IL15-01R Recombinant Rhesus Monkey IL15 Protein, His-tagged Yeast His
Rabbit IL15-863R Recombinant Rabbit IL15 protein, His-tagged E.coli His Asn49~Pro162
Bovine IL15-235B Recombinant Bovine Interleukin 15 Yeast N/A
Cattle IL15-859C Recombinant Cattle IL15 protein, His-tagged E.coli His Ala48~Ser162 (Accession # Q28028)
Cynomolgus / Rhesus macaque IL15-0177C Active Recombinant Cynomolgus / Rhesus macaque IL15 protein, His-tagged HEK293 His Asn49-Ser162
Equine IL15-253E Active Recombinant Equine Interleukin 15 Yeast N/A
Feline IL15-1099F Active Recombinant Feline IL15 E.coli N/A Asn49-Ser162
Goat IL15-2291G Recombinant Goat IL15 Protein, His-tagged E.coli N-His Thr27-Ser161
Guinea Pig IL15-80G Recombinant Guinea Pig IL-15 Yeast N/A
Guinea pig Il15-860G Recombinant Guinea pig Il15 protein, His & S-tagged E.coli His/S Ser49~Ser162 (Accession # Q75SZ9)
Porcine IL15-01P Active GMP Recombinant Porcine IL15 Protein, His-Tagged E.coli His
Rhesus Macaque IL15-2232R Recombinant Rhesus monkey IL15 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL15-2053R-B Recombinant Rhesus Macaque IL15 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL15-2053R Recombinant Rhesus Macaque IL15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sheep IL15-861S Recombinant Sheep IL15 protein, His-tagged E.coli His Asn49~Ser162 (Accession # Q9XSJ6)
Zebrafish IL15-3624Z Recombinant Zebrafish IL15 Mammalian Cell His
Zebrafish il15-1005Z Recombinant Zebrafish il15 Protein, His-tagged E.coli N-His Met1-Glu141
Pig IL15-263S Recombinant Swine IL15 Yeast N/A
Pig IL15-80P Recombinant Porcine Interleukin-15 E.coli N/A
Pig IL15-212P Active Recombinant Pig IL15 Protein (Thr49-Ser162), N-His tagged, Animal-free, Carrier-free E.coli N-His Thr49-Ser162
Pig IL15-1004P Recombinant Pig IL15 Protein, His-tagged E.coli N-His Thr49-Ser162
Pig IL15-147P Recombinant Active Pig IL15 Protein, His-tagged(N-ter) E.coli His(N-ter)
Chicken IL15-6140C Recombinant Chicken IL15 Mammalian Cell His
Chicken IL15-20C Recombinant Chicken IL-15 Yeast N/A
Chicken IL15-1006C Recombinant Chicken IL15 Protein, His-tagged E.coli N-His Asn67-Asn187
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL15 involved in several pathways and played different roles in them. We selected most pathways IL15 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTGFB3;CCL5;PRLR;TNFSF10;FASLG;IL15;CCL24;IL7;CCL27B
Jak-STAT signaling pathwayIfna15;GHR;IFNPHI3;IL12RB1;IL20;IL6;IL3;IFNA13;IFNB1
TNF signaling pathwayCFLAR;MAGI2;FADD;TRAF1;MMP3;RELA;MAPK8;FAS;IL18R1
Intestinal iTNFSF13;MAP3K14;ITGB7;H2-AA;TGFB1;HLA-DPA1;ITGA4;HLA-DQA1;HLA-DPB1
ne network for IgA productionH2-AA;HLA-DOA;BLB2;IL6;MHC2DAB;CCL25B;TGFB1A;H2-AB1;CCL28
HTLV-I infectionTGFB2;MAP2K4;TNFRSF1A;WNT1;PRKACB;STAT5B;TGFB1;KAT2B;MRAS
Herpes simplex infectionCD74;CSNK2A2A;EEF1D;HLA-DOB;PTPN11B;PER3;IFNA2;MCRS1;TLR2
Rheumatoid arthritisCD80;ATP6V0A2;ATP6V1B1;ATP6V1C1;Ccl12;ATP6V1E1;ANGPT1;ATP6V0E1;TLR4

IL15 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL15 itself. We selected most functions IL15 had, and list some proteins which have the same functions with IL15. You can find most of the proteins on our site.

Function Related Protein
cytokine activityTGFB1A;NDR1;TSLP;OSM;IFNA3;Flt3l;VSTM1;Ccl12;SP100
cytokine receptor bindingIFNA13;IL17A;IL15;IL17D;IL21;IL17A/F3;IL17F;IFNPHI4;Ifna11
protein bindingKCNG4;OLFM4;DKK1B;BLVRA;KATNA1;GCET2;PATL1;S1PR3;ZFAND2B

IL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL15.

IL2RB; IL15RA; STAT5B; TRAF3; ZNRD1

Research Area

Related articles

Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
  • Q&As
  • Reviews

Q&As (10)

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What techniques differentiate IL15 and IL2 receptor binding kinetics? 10/22/2022

Techniques discern IL15 and IL2 receptor binding kinetics.

What experimental methods study IL15's involvement in autoimmune diseases? 06/23/2022

Methods explore IL15's role in autoimmune disease mechanisms.

What are the applications of IL15 knockout models in deciphering its functions? 04/26/2022

IL15 knockout models provide insights into its diverse functions.

How do you analyze IL15's impact on memory T cell differentiation? 09/19/2021

IL15's influence on memory T cell differentiation investigated.

How does immunofluorescence microscopy visualize IL15 localization in cells? 07/26/2021

Immunofluorescence microscopy visualizes IL15 subcellular localization.

What approaches validate IL15's role in inflammatory responses? 02/04/2021

Approaches validate IL15's involvement in inflammatory responses.

Could you explain the role of IL15 in NK cell cytotoxicity assays? 10/26/2019

IL15's role in NK cell cytotoxicity analyzed using assays.

Can you detail the use of ELISA in quantifying IL15 secretion? 02/03/2018

ELISA measures IL15 secretion accurately.

How is IL15's effect on regulatory T cells quantified using qPCR? 06/08/2017

qPCR quantifies IL15's impact on regulatory T cells.

How does flow cytometry assess IL15-induced T-cell proliferation? 05/26/2017

Flow cytometry quantifies IL15-driven T-cell proliferation.

Customer Reviews (3)

Write a review
Reviews
04/19/2018

    Mapping protein- interactions in DNA transcription for gene regulation.

    02/20/2018

      Suitable for cytotoxicity assays.

      10/22/2017

        Effective in NK cell activation.

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