IL15
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Official Full Name
interleukin 15
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Background
Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. -
Synonyms
IL15; MGC9721; Interleukin-15 precursor; OTTHUMP00000164617; interleukin 15; IL-15;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL15 Related Articles
- IL15 Related Research Area
IL15 involved in several pathways and played different roles in them. We selected most pathways IL15 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNA17;IL28A;GH2;PLEKHO2;BMPR2A;IL1B;BMPR1AA;TGFBR1B;IFNA5 |
| Jak-STAT signaling pathway | CISH;PTPN6;IFNE;Gh;SOCS6B;PIK3R5;IL21R.1;GRB2B;IL9R |
| TNF signaling pathway | RELA;FADD;CREB3L2;SOCS3;MAP3K7IP3;IKBKB;PIK3R3;AKT1;CXCL2 |
| Intestinal i | H2-AA;BMA2;HLA-DRB4;IL5;BMA1;CCL28;HLA-DPB1;CCL25;BLA |
| ne network for IgA production | MADCAM1;CCR10;IL-15RA;ITGA4;CXCL12A;HLA-DQA2;HLA-DPA1;CCL25B;MHC2DCB |
| HTLV-I infection | SMAD4;RB1;PTTG2;APC2;XIAP;HLA-DPA1;Fzd4;FZD9;HLA-DOA |
| Herpes simplex infection | CD74;CCL2;CDC34A;NXF3;EIF2S1B;HMGN1;MAPK10;IL6;IFNA1 |
| Rheumatoid arthritis | IFNG;HLA-DRB3;HLA-DQA2;TLR4;ATP6V1B2;LTB;HLA-DMA;HLA-DRA;H2-AA |
IL15 has several biochemical functions, for example, cytokine activity, cytokine receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL15 itself. We selected most functions IL15 had, and list some proteins which have the same functions with IL15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | LFT2;IL25;WNT7A;GM13289;GDF11;INHBE;OSTN;FLT3LG;CER1 |
| cytokine receptor binding | IL17C;IFNA13;IFNPHI1;IL15;IL17A/F2;IFNA21;IL17A/F1;IFNW1;IL17A/F3 |
| protein binding | POMGNT1;VARS;DMPK;GGACT;TRIM44;ADAMTS13;VAMP2;RNF11;SPDYE2 |
IL15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL15 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL15.
IL2RB; IL15RA; STAT5B; TRAF3; ZNRD1
- Q&As
- Reviews
Q&As (10)
Ask a questionTechniques discern IL15 and IL2 receptor binding kinetics.
Methods explore IL15's role in autoimmune disease mechanisms.
IL15 knockout models provide insights into its diverse functions.
IL15's influence on memory T cell differentiation investigated.
Immunofluorescence microscopy visualizes IL15 subcellular localization.
Approaches validate IL15's involvement in inflammatory responses.
IL15's role in NK cell cytotoxicity analyzed using assays.
ELISA measures IL15 secretion accurately.
qPCR quantifies IL15's impact on regulatory T cells.
Flow cytometry quantifies IL15-driven T-cell proliferation.
Customer Reviews (3)
Write a reviewMapping protein- interactions in DNA transcription for gene regulation. -
Suitable for cytotoxicity assays. -
Effective in NK cell activation. -
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