Recombinant Mouse Il34 Protein, Myc/DDK-tagged

• Cat.No.: Il34-3523M
• Product Overview: Purified recombinant protein of mouse full-length interleukin 34 (Il34), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 26.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Il34 interleukin 34 [ Mus musculus (house mouse) ]
• Official Symbol: Il34
• Synonyms: IL34; interleukin 34; interleukin-34; IL-34; AI593503; 2010004A03Rik
• Gene ID: 76527
• mRNA Refseq: NM_001135100
• Protein Refseq: NP_001128572
• UniProt ID: Q8R1R4

Reviews

05/10/2021

IL34 has shown good biocompatibility and safety in related experiments.

01/19/2020

When using IL34 for experiments, the experimental conditions and results are highly repeatable.

10/24/2019

Quality is stable and reliable, with no significant differences between batches.

Q&As

What is the effect of IL34 on tumor prognosis?

There are no clear studies showing the effect of IL34 on tumor prognosis.

What are the advantages of IL34 over other treatments?

Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.

What is the mechanism of action of IL34 in the treatment of tumor?

May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.

How is the clinical trial of IL34 progressing?

No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.

How does IL34 affect the immune system?

Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.

How to evaluate the efficacy of IL34?

The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.