Recombinant Mouse Il6st protein, His/S-tagged
Cat.No. : | Il6st-222M |
Product Overview : | Recombinant Mouse Il6st fused with His/S tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
Source : | E. coli |
Species : | Mouse |
Tag : | His/S |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Store at -70 centigrade. Avoid repeated freeze/thaw cycles. |
Gene Name : | Il6st interleukin 6 signal transducer [ Mus musculus ] |
Official Symbol : | Il6st |
Synonyms : | IL6ST; interleukin 6 signal transducer; interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik; |
Gene ID : | 16195 |
mRNA Refseq : | NM_010560 |
Protein Refseq : | NP_034690 |
UniProt ID : | Q00560 |
Chromosome Location : | 13 D2.2; 13 63.73 cM |
Pathway : | Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; ESC Pluripotency Pathways, organism-specific biosystem; IL-6 signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; |
Function : | ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; contributes_to interleukin-11 binding; contributes_to interleukin-11 receptor activity; interleukin-6 receptor activity; protein binding; protein heterodimerization activity; |
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◆ Lysates | ||
IL6ST-946CCL | Recombinant Cynomolgus IL6ST cell lysate | +Inquiry |
IL6ST-935HCL | Recombinant Human IL6ST cell lysate | +Inquiry |
IL6ST-001MCL | Recombinant Mouse IL6ST cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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